 | Christopher McCulloch als Hank Venture / The Monarch / Hunter Gathers (voice) |
 | Doc Hammer als Henchman 21 / Dr. Mrs. The Monarch / Billy Quizboy (voice) |
 | James Urbaniak als Dr. Venture / Phantom Limb / Jonas Venture Jr. (voice) |
 | Michael Sinterniklaas als Dean Venture (voice) |
 | Patrick Warburton als Brock Samson (voice) |
 | Nina Arianda als Mantilla (voice) |
 | Clancy Brown als Red Death / Daisy (voice) |
 | John Hodgman als Snoopy (voice) |
 | Hal Lublin als Clayton (voice) |
 | Jane Lynch als Bobbi St. Simone (voice) |
 | Charles Parnell als Jefferson Twilight (voice) |
 | Jay Pharoah als Nuno Blood (voice) |
 | Steven Rattazzi als Dr. Orpheus (voice) |
 | J.K. Simmons als Ben (voice) |
 | Dana Snyder als The Alchemist (voice) |
| Christopher McCulloch | Writer |
| Doc Hammer | Writer |
| Christopher McCulloch | Director |
| Tony Salama | Producer |
| J.G. Thirlwell | Music |
| Rachel Simon | Producer |
| Chris Prynoski | Executive Producer |
| Antonio Canobbio | Executive Producer |
| Ben Kalina | Executive Producer |
| Todd Raleigh | Editor |
| Doc Hammer | Executive Producer |
| Christopher McCulloch | Executive Producer |
| Gabriel Lee | Assistant Director |
| Christine Terry | Casting |
| Jackie Sollitto | Casting |
| Shannon Prynoski | Executive Music Producer |
