 | Brendan Fraser als Dan Sanders |
 | Brooke Shields als Tammy Sanders |
 | Ken Jeong als Neal Lyman |
 | Matt Prokop als Tyler Sanders |
 | Angela Kinsey als Felder |
 | Skyler Samuels als Amber |
 | Ricky Garcia als Frank |
 | Eugene Cordero als Cheese |
 | Patrice O'Neal als Gus |
 | Jim Norton als Hank |
 | Billy Bush als Drill Sergeant |
 | Samantha Bee als Principal Baker |
 | Alice Drummond als Mrs. Martin |
 | Toby Huss als Wilson |
 | Gerry Bednob als Mr. Gupta |
 | Alexander Chance als Security Guard |
 | Dee Bradley Baker als Animals (voice) |
 | D.C. Pierson als Student (uncredited) |
 | Rob Riggle als Riggs (uncredited) |
 | Wallace Shawn als Dr. Christian Burr (uncredited) |
| Mohamed Khalaf Al-Mazrouei | Executive Producer |
| Brendan Fraser | Executive Producer |
| Ira Shuman | Executive Producer |
| Robert Simonds | Producer |
| Keith Goldberg | Producer |
| Ed Shearmur | Original Music Composer |
| Peter Lyons Collister | Director of Photography |
| Terri Goddard | Co-Producer |
| Lawrence Jordan | Editor |
| Jeff Skoll | Executive Producer |
| E. David Cosier | Art Direction |
| Stephen J. Lineweaver | Production Design |
| Jennifer Engel | Set Decoration |
| Molly O'Keefe | Associate Producer |
| Roger Kumble | Director |
| Alexandra Welker | Costume Design |
| Michael Carnes | Writer |
| Michael D. Wilhoit | Supervising Sound Editor |
| Mathew Waters | Sound Re-Recording Mixer |
| Joe Barnett | Sound Re-Recording Mixer |
| Terri Douglas | ADR Voice Casting |
| Jennifer Euston | Casting |
| Frederick H. Stahly | Dialogue Editor |
| Josh Gilbert | Writer |
| Ernie F. Orsatti | Stunt Coordinator |
