 | Robert De Niro als Jack Walsh |
 | Charles Grodin als Jonathan Mardukas |
 | Yaphet Kotto als Alonzo Mosely |
 | John Ashton als Marvin Dorfler |
 | Dennis Farina als Jimmy Serrano |
 | Joe Pantoliano als Eddie Moscone |
 | Richard Foronjy als Tony Darvo |
 | Robert Miranda als Joey |
 | Jack Kehoe als Jerry Fleisher |
 | Wendy Phillips als Gail |
 | Philip Baker Hall als Sidney |
 | Tom Irwin als FBI Agent Perry |
 | Jimmie Ray Weeks als FBI Agent Tuttle |
| Danielle DuClos als Denise |
 | Tom McCleister als Red Wood (as Thom McCleister) |
| Mary Gillis als Bus Ticket Clerk |
 | John Toles-Bey als Monroe Bouchet |
| Thomas J. Hageboeck als Sergeant Gooch |
| Stanley White als Stanley |
 | Scott McAfee als Boy on Plane |
| Linda Cerasuolo als Car Rental Clerk (as Linda Margules) |
 | Lois Smith als Mrs. Nelson |
 | Fran Brill als Dana Mardukas |
 | Michael Hawkins als FBI Surveillance Agent #1 (as Michael D. Gainsborough) |
 | John Hammil als FBI Surveillance Agent #2 |
 | Lou Felder als Airline Pilot |
| Cameron Milzer als Stewardess #1 |
| Sonia M. Roberts als Stewardess #2 |
| Sam Sanders als Train Porter |
 | Frank Pesce als Carmine |
| Paul Joseph McKenna als Ohio Policeman |
| Matt Jennings als Jason |
| Rosemarie Murphy als Coffee Shop Waitress |
| Jack N. Young als Amarillo Desk Sergeant |
| Robert Coleman als Native American |
| William Robbins als Native American |
| Wilfred Netsosie als Native American |
| Sherman L. Robbins als Native American |
| Dale Beard Jr. als Native American |
| Thomas Nez als Native American |
| Richard Gonzalez als Bar Cashier |
| Bill Fritz als Bar Customer |
| Pete Jensen als Flagstaff Police Captain |
| Andy Charnoki als Flagstaff Sheriff |
 | Tracey Walter als Diner Counter Man |
| Robert Vento als Serrano Bodyguard |
| Joe "Tippy" Zeoli als Serrano Bodyguard |
| James Portolese als Serrano Bodyguard (as Jim Portese) |
| Armando Muniz als Serrano Bodyguard |
| Dan York als Las Vegas FBI Agent #1 |
| Rowdy Burdick als Las Vegas FBI Agent #2 |
| Varnoy Lee als Airport Porter |
 | Bob Maroff als L.A. Taxi Driver |
 | Martin Brest als Airline Ticket Clerk (uncredited) |
| Lisa Burnett als Undercover Cop (uncredited) |
| Jeff Dlugolecki als Pedestrian (uncredited) |
| George D. Miklos als Airport Manager (uncredited) |
| Robert Minkoff als Man (uncredited) |
| Marguerite Nocera als Ticket Clerk (uncredited) |
 | Terry Ray als Deplaning Passenger (uncredited) |
| Jock L. Schloss als Man (uncredited) |
 | D. Danny Warhol als Station Commuter (uncredited) |
| Martin Brest | Director |
| George Gallo | Screenplay |
| Martin Brest | Producer |
| Danny Elfman | Original Music Composer |
| Chris Lebenzon | Editor |
| Donald E. Thorin | Director of Photography |
| Michael Tronick | Editor |
| Billy Weber | Editor |
| Michael Chinich | Casting |
| Bonnie Timmermann | Casting |
| Angelo P. Graham | Production Design |
| James J. Murakami | Art Direction |
| George R. Nelson | Set Decoration |
| Gloria Gresham | Costume Design |
| Clarence Lynn Price | Construction Coordinator |
| Roy Arbogast | Special Effects Supervisor |
| David Gonzales | Casting Associate |
| G. Tony Scarano | Costume Supervisor |
| Wilma Garscadden-Gahret | Script Supervisor |
| Dan Perri | Title Designer |
| Ross Reynolds | Pilot |
| Mike Johnson | Stunts |
| Ian MacGregor-Scott | Sound Editor |
| William S. Gilmore | Executive Producer |
| Frank Griffin | Makeup Artist |
| Daniel C. Striepeke | Makeup Artist |
| Erik Cord | Stunts |
| Eddie Hice | Stunts |
| Thomas Rosales Jr. | Stunts |
| Larry Holt | Stunts |
| Christine Lee | Hairstylist |
| Daniel J. Leahy | Sound Re-Recording Mixer |
| Andy MacDonald | Sound Re-Recording Mixer |
| James Bolt | Sound Re-Recording Mixer |
| Joel Fein | Sound Re-Recording Mixer |
| Rick Alexander | Sound Re-Recording Mixer |
| John Stacy | Supervising Sound Editor |
| Glenn Hoskinson | Sound Editor |
| David A. Whittaker | Supervising Sound Editor |
| Pete Antico | Stunts |
| Geoff Brewer | Stunts |
| Tony Brubaker | Stunts |
| Roydon Clark | Stunts |
| Blair Burrows | Stunts |
| Richard E. Butler | Stunts |
| Brian Burrows | Stunts |
| Justin De Rosa | Stunts |
| Corey Michael Eubanks | Stunts |
| Greg Wayne Elam | Stunts |
| Gene Hartline | Stunts |
| Bill Hart | Stunts |
| Orwin C. Harvey | Stunts |
| Clifford Happy | Stunts |
| Kent Hays | Stunts |
| John Moio | Stunts |
| William T. Lane | Stunts |
| Spiro Razatos | Stunts |
| Glenn Randall Jr. | Stunt Coordinator |
| Dennis Scott | Stunts |
| Jerry Summers | Stunts |
| Mario Roberts | Stunts |
| Neil Summers | Stunts |
| Dick Warlock | Stunts |
| Rock A. Walker | Stunts |
| Jim Wilkey | Stunts |
| Gary J. Wayton | Stunts |
| Cliff Fleming | Pilot |
| Bill Warren, Jr. | Pilot |
| Larry Powell | Unit Production Manager |
| Murray Schwartz | Unit Production Manager |
| Jerry Ziesmer | First Assistant Director |
| William M. Elvin | First Assistant Director |
| Alan Edmisten | Second Assistant Director |
| Bryan Denegal | Second Assistant Director |
| Vicki Jackson-Lemay | Second Assistant Director |
| Glenn Randall Jr. | Second Unit Director |
| David J. Negrón Jr. | Production Illustrator |
| Rob Hahn | Camera Operator |
| Michael Gershman | Camera Operator |
| Daniel C. Gold | First Assistant Camera |
| Matthew E. Alper | Second Assistant Camera |
| Richard Foreman Jr. | Still Photographer |
| James R. Alexander | Sound Mixer |
| Greg Agalsoff | Boom Operator |
| Steve Agalsoff | Cableman |
| James F. Boyle | Gaffer |
| Robin Alan Knight | Key Grip |
| Dan York | Associate Producer |
| Dino Ganziano | Hairstylist |
| Bill Borden | Production Supervisor |
| Margaret Hilliard | Production Manager |
| Jeff Stolow | Production Manager |
| Grant Gilmore | Second Second Assistant Director |
| Charles Brescia | Second Second Assistant Director |
| David Aaron | Assistant Property Master |
| Robert J. Carlyle | Construction Foreman |
| Kimberly Clancy | Art Department Assistant |
| Roger Dietz | Standby Painter |
| Emily Ferry | Property Master |
| Peter J. Kelly | Set Designer |
| Donald Krafft | Leadman |
| Bill Luckey | Assistant Property Master |
| Roderick Nunnally | Standby Painter |
| Roger Pancake | Property Master |
| Mark Wade | Property Master |
| John Ballowe | Assistant Art Director |
| Mychael Bates | Set Dresser |
| Christopher Gilman | Props |
| Sean Haworth | Art Department Assistant |
| Greg Knapp | Set Medic |
| Brick Mason | Storyboard Artist |
| Timothy W. Tiedje | Property Master |
| Cindy Marty | Dialogue Editor |
| Andrew Patterson | Sound Editor |
| Christy Richmond | Assistant Sound Editor |
| Albert Romero | Sound Recordist |
| David Spence | Sound Editor |
| Greg Stacy | Sound Editor |
| Marvin Walowitz | Sound Editor |
| Denise Whiting | ADR Editor |
| Karen G. Wilson | Sound Editor |
| Kyle Wright | Sound Editor |
| Thomas Paul Croce | Foley Artist |
| Steve Kohler | Sound |
| Solange S. Schwalbe | Sound Editor |
| Thomas Whiting | ADR Editor |
| David Blitstein | Special Effects |
| Gaile R. Brown | Special Effects |
| Jeff Frink | Special Effects |
| Thomas Love | Special Effects |
| Paul Sabourin | Special Effects |
| Neil Smith | Special Effects |
| Randy Cabral | Special Effects |
| Robert Cole | Special Effects Technician |
| Gary L. King | Special Effects |
| Holly Bower | Still Photographer |
| Frank M. Holgate | Aerial Camera |
| Jeffrey R. Clark | Assistant Camera |
| Steve Clark | Key Grip |
| Daniel Dayton | Assistant Camera |
| T. Sano Kwong | Best Boy Grip |
| David L. Merrill | Dolly Grip |
| Stephen G. Shank | Camera Operator |
| Robert Sordal | Key Grip |
| John M. Stephens | Aerial Director of Photography |
| Omar Abderrahman | Electrician |
| Paolo Cascio | Second Assistant Camera |
| Richie Ford | Gaffer |
| Dave Friedman | Still Photographer |
| Douglas Kirkland | Still Photographer |
| Roland Neveu | Additional Still Photographer |
| Joseph A. Ponticelle | First Assistant Camera |
| Dennis Seawright | Camera Loader |
