 | Jake Gyllenhaal als Searcher Clade (voice) |
 | Dennis Quaid als Jaeger Clade (voice) |
 | Jaboukie Young-White als Ethan Clade (voice) |
 | Gabrielle Union als Meridian Clade (voice) |
 | Lucy Liu als Callisto Mal (voice) |
 | Alan Tudyk als Narrator / Radio Host 1 / Duffle (voice) |
 | Jonathan Melo als Diazo (voice) |
 | Abraham Benrubi als Lonnie Redshirt (voice) |
 | Karan Soni als Caspian (voice) |
 | Adelina Anthony als Pulk (voice) |
 | Nik Dodani als Kardez (voice) |
 | Francesca Reale als Azimuth (voice) |
 | Emily Kuroda als Ro (voice) |
 | Reed Buck als Rory (voice) |
 | Katie Lowes als Radio Host 2 (voice) |
 | LaNisa Renee Frederick als Client #2 (voice) |
 | Dave Kohut als Client #3 (voice) |
| Alice Kina Diehl als Client #4 (voice) |
| Don Hall | Director |
| Qui Nguyen | Screenplay |
| Roy Conli | Producer |
| Jennifer Lee | Executive Producer |
| Mehrdad Isvandi | Production Design |
| Ian Gooding | Art Direction |
| Larry Wu | Art Direction |
| Sean Creveling | Production Supervisor |
| Steven Crowe | Production Supervisor |
| Steph Gortz | Production Supervisor |
| Brandon Holmes | Production Supervisor |
| Jonny Hylton | Production Supervisor |
| Dave Kohut | Production Supervisor |
| Nora Rogers | Production Supervisor |
| Mia Calderone | Storyboard Artist |
| Clio Chiang | Storyboard Artist |
| Don Dougherty | Storyboard Artist |
| Ryan Green | Storyboard Artist |
| Teny Issakhanian | Storyboard Artist |
| Carrie Liao | Story Artist |
| Jose Francisco Martinez | Visual Development |
| Ryn Soorholtz | Production Coordinator |
| David E. Fluhr | Sound Supervisor |
| Gabriel Guy | Sound Re-Recording Mixer |
| Oscar A. Ayala | Character Modelling Supervisor |
| Chrisy Baek | Lighting Artist |
| Bob Bennett | Effects Supervisor |
| Chris Carignan | Visual Effects |
| Deborah Carlson | Effects Supervisor |
| Grace C. Kim | Casting Associate |
| Adam DesCombes | First Assistant Editor |
| Anthony Durazzo | Associate Editor |
| Michael Weissman | First Assistant Editor |
| Tyler Durham | Music Programmer |
| Andrew Kinney | Orchestrator |
| Tom MacDougall | Executive Music Producer |
| Thai Bettistea | Script Coordinator |
| Paul Aichele | Animation Technical Director |
| Theresa Adolph | Animation |
| Manar Al Tawam | Animation |
| David Badgerow | Animation |
| Ozan Basaldi | Animation |
| Tony Bonilla | Animation |
| Abby Boyce | Animation |
| Stephen Dahler | Animation |
| Anthony DeRosa | Animation |
| Pete Devlin | Animation |
| Nathan Dillow | Animation |
| Janel Drewis | Animation |
| Andrew Feliciano | Animation Supervisor |
| Jason Figliozzi | Animation Supervisor |
| Michael Franceschi | Animation Supervisor |
| Kitty Fung | Animation |
| Pedro Daniel García Pérez | Animation |
| Taylor Gessler | Animation |
| Ben Girmann | Animation |
| Hector Godoy Garcia | Animation |
| Eric Goldberg | Head of Animation |
| Laura H. Han | Animation |
| Dave Hardin | Animation |
| Kim Hazel | Animation Supervisor |
| Amy Henkels | Story Artist |
| Jason Herschaft | Animation |
| Seth Hippen | Animation |
| Teny Issakhanian | Story Artist |
| Mitchell Jao | Animation |
| Andrew Jennings | Character Technical Supervisor |
| Louis Jones | Animation |
| Ken Kaiser | Animation |
| Yohei Koike | Animation |
| Megan Kreiner | Animation |
| Andrew Lawson | Animation |
| Hannah Leung | Story Artist |
| Jonathan Lin | Modeling |
| Caitlin Low | Animation |
| Kevin MacLean | Animation |
| Boris Maras | Animation |
| Paula Benedicto Martinez | Animation |
| Naoko Mizutori | Animation |
| Michael Anthony Navarro | Character Technical Supervisor |
| Haengsook Oh | Modeling |
| Olga Parshina | Animation |
| Nicklas Puetz | Character Technical Supervisor |
| Mitja Rabar | Animation |
| Zachary Rahman | Animation |
| Krista Rogers | Animation |
| Albert Rubio | Animation |
| Mikee Sevilla | Animation |
| Jonah Sidhom | Animation |
| Chatrasal Singh | Animation |
| Justin Sklar | Head of Animation |
| Alexander Snow | Animation |
| David Stodolny | Animation Supervisor |
| Shay Stone | Animation |
| Wes Storhoff | Animation |
| Gregory Verreault | Animation |
| Vitor Vilela | Animation Supervisor |
| Malerie Walters | Animation |
| Gina Warr | Lighting Supervisor |
| Emma Wolfe | Modeling |
| Mikey Wong | Animation |
| Trevor Young | Animation |
| Masahito Yoshioka | Visual Effects |
| Robert Zhou | Visual Effects |
| Emily Yi | Lighting Artist |
| Irene Weng | Visual Effects Technical Director |
| Rebecca Vallera-Thompson | Visual Effects Technical Director |
| Lisa M. Tse | Visual Effects Technical Director |
| Le Joyce Tong | Visual Effects |
| Marie Tollec | Visual Effects |
| Ka Yaw Tan | Lighting Artist |
| Ashley Souza | Lighting Artist |
| Catlin Scroggie | Lighting Artist |
| Afonso Salcedo | Lighting Artist |
| Olun Riley | Lighting Supervisor |
| Luke Pikora | Lighting Artist |
| R.J. Peña | Lighting Artist |
| Miguel Perez | Lighting Artist |
| Ash Ogasawara | Lighting Artist |
| Robert L. Miles | Lighting Artist |
| Chris Patrick O'Connell | Modeling |
| James Joshua Lojo | Lighting Artist |
| Kendall Litaker | Visual Effects Technical Director |
| Walker Kennedy | Lighting Artist |
| Austin Hirsch | Lighting Artist |
| Luke Heathcock | Lighting Artist |
| Qui Nguyen | Co-Director |
| Brian Adams | Lighting Artist |
| Shannon Mills | Sound Designer |
| Shannon Mills | Supervising Sound Editor |
| Samson Neslund | Sound Designer |
| Brad Semenoff | ADR Supervisor |
| Burny Mattinson | Story Artist |
| David G. Derrick Jr. | Head of Story |
| Henry Jackman | Original Music Composer |
