 | George Clooney als Lyn Cassady |
 | Ewan McGregor als Bob Wilton |
 | Jeff Bridges als Bill Django |
 | Kevin Spacey als Larry Hooper |
 | Robert Patrick als Todd Nixon |
 | Stephen Lang als Brigadier General Dean Hopgood |
 | Waleed Zuaiter als Mahmud Daash |
 | Stephen Root als Gus Lacey |
 | Glenn Morshower als Major General Holtz |
 | Nick Offerman als Scotty Mercer |
 | Tim Griffin als Tim Kootz |
 | Rebecca Mader als Debora Wilton |
 | Jacob Browne als Lieutenant Boone |
 | Todd Lawson LaTourrette als Dave |
 | Brad Grunberg als Ron |
| Elsa Villafane als Gus' Mother |
 | Fawad Siddiqui als Kuwait Waiter |
 | Samuel Ray Gates als Journalist #1 |
 | McCaleb Burnett als Journalist #2 |
 | Robert Curtis Brown als General Brown |
 | Hrach Titizian als Kidnapper #1 |
 | Shafik N. Bahou als Kidnapper #2 |
 | Christopher Maher als Iraqi Driver |
 | Matt Newton als Chris - Viet Nam Pvt. |
 | Kevin Wiggins als Major General Jack Gillian |
| JJ Raschel als Clifford Hickox |
 | Arron Shiver als Norm Pendleton |
| Jaime Margarida als Major General Pendleton |
 | William Sterchi als Bob's Editor |
| Drew Seltzer als Technician |
| Donn Lamkin als Lyn's Father |
 | Sean Curley als Lyn (12 years old) |
| Michael-David Aragon als Insurgent |
 | Morse Bicknell als Ben Echmeyer |
 | Kevin Geer als CIA Agent |
 | Chick Bernhard als Krom - SUV |
| Grant Heslov | Director |
| Jon Ronson | Novel |
| Peter Straughan | Screenplay |
| Christopher T. Welch | Dialogue Editor |
| Cathy Sandrich Gelfond | Casting |
| George Clooney | Producer |
| Grant Heslov | Producer |
| Paul Lister | Producer |
| Rolfe Kent | Original Music Composer |
| Robert Elswit | Director of Photography |
| Tatiana S. Riegel | Editor |
| Amanda Mackey | Casting |
| Sharon Seymour | Production Design |
| Peter Borck | Art Direction |
| Louise Frogley | Costume Design |
| Martial Corneville | Wig Designer |
| Ken Diaz | Makeup Department Head |
| Waldo Sanchez | Hair Designer |
| Jay Wejebe | Key Makeup Artist |
| David Webb | First Assistant Director |
| Andrew Petrotta | Property Master |
| Robert Jackson | Boom Operator |
| Mark A. Mangini | Sound Designer |
| Piero Mura | Sound Effects Editor |
| George Simpson | Sound Effects Editor |
| Christopher T. Welch | ADR Editor |
| Kevin Harris | Special Effects Coordinator |
| Thomas J. Smith | Visual Effects Supervisor |
| Jeffrey Lee Gibson | Stunt Coordinator |
| Colin Anderson | Camera Operator |
| Laura Magruder | Still Photographer |
| Rick Thomas | Chief Lighting Technician |
| Deborah Andrews | Seamstress |
| Tom Cummins | Key Set Costumer |
| Ali Lammari | Set Costumer |
| Richard Schoen | Costume Supervisor |
| Linda Cohen | Music Supervisor |
| Tony Blondal | Orchestrator |
| Nick South | Music Editor |
| Elizabeth Himelstein | Dialect Coach |
| Coraly Santaliz | Script Supervisor |
| Barbara A. Hall | Executive Producer |
| James A. Holt | Executive Producer |
| Alison Owen | Executive Producer |
| David M. Thompson | Executive Producer |
| Ellen Gordon | Unit Production Manager |
| Barbara A. Hall | Unit Production Manager |
| John R. Saunders | Second Assistant Director |
| Luillo Ruiz | Associate Producer |
| Michelle Lankwarden | Production Supervisor |
| Charlene Olson | Production Supervisor |
| Jim Passon | Color Timer |
| Mónica Monserrate | Set Decoration |
| Marcia Calosio | Set Decoration |
| Amahl Lovato | Set Designer |
| Edward Tise | Sound Mixer |
| Adam Barth | Video Assist Operator |
| Pablo Prietto | First Assistant Editor |
| Jeff Kunkle | Dolly Grip |
| Ian Calip | Second Second Assistant Director |
| Jim Swidarski | Payroll Accountant |
| Matthew Iadarola | Sound Re-Recording Mixer |
| Mark A. Mangini | Sound Re-Recording Mixer |
| Dean St. John | ADR Mixer |
| Andy Malcolm | Foley Artist |
| Goro Koyama | Foley Artist |
| Caoimhe Doyle | Foley Artist |
| Christian Prejza | Digital Intermediate Producer |
| Devon Miller | Digital Intermediate Editor |
| Al Goto | Utility Stunts |
| Chick Bernhard | Stunt Driver |
| Ed Duran | Stunt Driver |
| Bobby Burns | Stunts |
| Pat Banta | Stunt Double |
| Bobby Beckles | Stunt Driver |
| Alan D'Antoni | Stunt Double |
| Jorge Cisneros | Stunt Double |
| Ramon Frank | Stunts |
| Vince Deadrick Jr. | Stunt Double |
| Scott M. Helgert | Stunts |
| Drew Leary | Stunt Double |
| Jaime Irizarry | Stunts |
| Erik Martin | Stunts |
| Jalil Jay Lynch | Stunt Driver |
| Anthony Molinari | Stunt Double |
| John Prudhont | Stunt Driver |
| Peewee Piemonte | Utility Stunts |
| Merik Tadros | Stunts |
| Jay Spadaro | Stunt Driver |
| Jay Spadaro | Stunts |
| Mark Aaron Wagner | Stunt Double |
| Edward Conna | Stunt Double |
| Loyd Catlett | Stunt Double |
