 | Jean-Claude Van Damme als Luc Deveraux |
 | Scott Adkins als John |
 | Dolph Lundgren als Andrew Scott |
 | Andrei Arlovski als Magnus |
 | Mariah Bonner als Sarah |
 | Audrey P. Scott als Emma |
 | Rus Blackwell als Agent Gorman |
 | James DuMont als Dr. Timothy Brady |
 | Dane Rhodes als Ron Castellano |
 | David Jensen als Dr. Su |
 | Kris Van Damme als Miles |
 | Sigal Diamant als Claudia |
 | Juli Erickson als Woman |
 | Andrew Sikking als Larry |
 | Tony Jarreau als Bouncer |
 | Craig Walker als Earl |
 | Roy Jones Jr. als Mess Hall Unisol |
| Susan Mansur als Madame |
 | James Rawlings als Unisol (uncredited) |
 | Arnold Chon als Unisol |
 | Dennis Keiffer als Unisol |
 | Woon Young Park als Unisol |
| Mike Wilson als Unisol |
| John Hyams | Director |
| John Hyams | Screenplay |
| Doug Magnuson | Screenplay |
| Moshe Diamant | Story |
| Wil Hendricks | Original Music Composer |
| Michael Krassner | Original Music Composer |
| Brent Caballero | Casting |
| John Hyams | Story |
| Jon Greenhalgh | Screenplay |
| Richard Rothstein | Characters |
| Christopher Leitch | Characters |
| Yaron Levy | Director of Photography |
| Andrew Drazek | Editor |
| John Hyams | Editor |
| Nate Jones | Production Design |
| Kim Martínez | Costume Design |
| Robin Vining | Original Music Composer |
| Dean Devlin | Characters |
| Moshe Diamant | Producer |
| Jeremy Woolsey | Art Direction |
| Andrew W. Bofinger | Set Decoration |
| David Atherton | Makeup Department Head |
| Hannah Gates | Costume Supervisor |
| Nancy Young | Stunts |
| Andrea Young | Hair Department Head |
| Kat Percy | Key Hair Stylist |
| Mark Landon | Key Makeup Artist |
| Erin Foster | Art Department Coordinator |
| Steve J. Jones | Construction Coordinator |
| Jonathan Shaffer | Property Master |
| Nicholas Davidoff | Steadicam Operator |
| Ari Robbins | Steadicam Operator |
| Andy Steinman | Second Unit Director of Photography |
| Sean P. Fickert | Dolly Grip |
| Michael Chateauneuf | Gaffer |
| Mark Shane Davis | Key Grip |
| Cook Allender | Still Photographer |
| Michael Nelson | Ultimate Arm Operator |
| Sean Paul Braud | Animal Wrangler |
| Jeff Galpin | Animal Wrangler |
| Andres Sepulveda | Armorer |
| David Lee Valle | Armorer |
| Mary Tallman | Script Supervisor |
| Jeremy Pleasant | Music Supervisor |
| Ievgen Kulieshov | 3D Artist |
| Roman Bazyuchenko | Visual Effects Producer |
| Tarn Fox | Visual Effects Producer |
| Ilia Goncharov | Visual Effects Supervisor |
| Oleksandr Kucherov | Visual Effects Supervisor |
| Ilya Lindberg | Visual Effects Supervisor |
| D.J. Shea | Visual Effects Supervisor |
| Everett Byrom III | Special Effects Supervisor |
| Megan Daly | Key Set Costumer |
| Melissa Naccari Floyd | Set Costumer |
| Kizzie Autumn Martin | Set Costumer |
| Michael Baird | ADR Editor |
| Michael Baird | Boom Operator |
| Shaun Brennan | Foley |
| Neil Fazzari | Sound Designer |
| Abigail Savage | Sound Effects Editor |
| Tom Efinger | Sound Re-Recording Mixer |
| Paul Bercovitch | Dialogue Editor |
| Allen Shapiro | Producer |
| Craig Baumgarten | Producer |
| Oleh Verenko | Digital Compositor |
| Yoram Barzilai | Line Producer |
| Lori Burchfield | Associate Producer |
| Keith Collea | Associate Producer |
| Stacy Frankel | Associate Producer |
| Steven A. Frankel | Executive Producer |
| James Gibb | Executive Producer |
| James Portolese | Associate Producer |
| Bobby Ranghelov | Executive Producer |
| Katerina Slantcheva | Associate Producer |
| Courtney Solomon | Executive Producer |
| Gregory M. Walker | Executive Producer |
| Mark Damon | Executive Producer |
| Mike Wilson | Stunts |
| Christine Craft Regusa | Stunt Driver |
| Chuck Picerni Jr. | Stunt Coordinator |
| Charlie Picerni | Stunt Coordinator |
| Chuck Picerni Jr. | Second Unit Director |
| Jessica Williams | Stunts |
| Scott Wilder | Stunts |
| Danny Epper | Stunts |
| Chelsea Bruland | Stunt Double |
