 | Charlize Theron als Æon Flux |
 | Marton Csokas als Trevor Goodchild |
 | Jonny Lee Miller als Oren Goodchild |
 | Sophie Okonedo als Sithandra |
 | Frances McDormand als Handler |
 | Pete Postlethwaite als Keeper |
 | Amelia Warner als Una Flux |
 | Caroline Chikezie als Freya |
 | Nikolai Kinski als Claudius |
 | Paterson Joseph als Giroux |
 | Yangzom Brauen als Inari |
 | Aoibheann O'Hara als Scientist |
 | Thomas Huber als Scientist |
 | Weijian Liu als Scientist |
 | Maverick Quek als Chemist |
 | Ralph Herforth als Gardener |
 | Megan Gay als Weaver |
 | Rainer Will als Commander Puhl |
 | Charlie Beall als Lieutenant Ord |
 | Bruno Bruni, Jr. als Armory Soldier (as Bruno Bruni) |
 | Ronald Marx als Bregnan Police Captain |
 | Axel Schreiber als Policeman |
| Katie Mullins als Neighbor |
 | Shaun Lawton als Man in Marketplace |
| Terry Bartlett als Monican Spy |
 | Betty Okino als Monican Spy |
 | Anatole Taubman als Sasha Prillo's Father |
 | Lavinia Wilson als Sasha Prillo's Mother |
 | Khira Lilli Pobanz als Sasha Prillo (Baby Una) |
 | William Morts als Guard |
 | Phil Hay als Soldier |
 | Nils Dommning als Young Trevor |
 | Bojan Heyn als Young Oren |
| Justin Schierlo als Boy at Wall |
 | Marianne Sonneck als Boy's Mother |
 | Joost Siedhoff als Crier |
| Tamara Röhl als Crier |
 | Narges Rashidi als Pregnant Woman |
| Claas Würfel als Husband |
 | Robin Gooch als Doctor |
| Anna De Carlo als Bregnan Victim |
 | Martha Fessehatzion als Checkpoint Woman |
 | Milton Welsh als Monican Man |
 | Mehmet Yilmaz als Monican Man |
| Alex Benjamin als Monorail Passenger |
 | Natacza Boon als Monorail Passenger |
| Clio Burggraeve als Monorail Passenger |
| Alexander Flache als Monorail Passenger |
 | Lilja Loeffler als Monorail Passenger |
| Kim Pfeiffer als Monorail Passenger |
 | Michael Pink als Monorail Passenger |
| Joachim Schönfeld als Monorail Passenger |
| Claudine Biswas-MacKenzie als Monorail Passenger (uncredited) |
| Jannik Büddig als Monorail Passenger (uncredited) |
 | Peggy Flood als Scientist (voice) (uncredited) |
 | Mirko Lang als Monorail Passenger (uncredited) |
| Mickey Nedimovic als Monorail Passenger (uncredited) |
| Karolin Oesterling als Monorail Passenger (uncredited) |
 | Wil Röttgen als Man in Museum (uncredited) |
 | Wolfgang Stegemann als Shock Trooper (uncredited) |
 | Stuart Townsend als Monican (uncredited) |
 | Timmi Trinks als Young Bregnaner (uncredited) |
| Karyn Kusama | Director |
| Phil Hay | Screenplay |
| Matt Manfredi | Screenplay |
| Stuart Dryburgh | Director of Photography |
| Graeme Revell | Original Music Composer |
| Andrew McAlpine | Production Design |
| Martha Griffin | Producer |
| Gale Anne Hurd | Producer |
| Gary Lucchesi | Producer |
| Tom Rosenberg | Executive Producer |
| Van Toffler | Executive Producer |
| Peter Chung | Characters |
| Jeff Gullo | Editor |
| Peter Honess | Editor |
| Plummy Tucker | Editor |
| Karen Lindsay-Stewart | Casting |
| Laura Rosenthal | Casting |
| Gregory Goodman | Producer |
| David Gale | Producer |
| Charlie Woebcken | Associate Producer |
| Henning Molfenter | Associate Producer |
| Marco Bittner Rosser | Art Direction |
| Sarah Horton | Art Direction |
| Andreas Olshausen | Art Direction |
| John Frankish | Supervising Art Director |
| Gary Freeman | Supervising Art Director |
| Bernhard Henrich | Set Decoration |
| Beatrix Aruna Pasztor | Costume Design |
| Sonja Bream-Winzenried | Art Department Assistant |
| Ingeborg Heinemann | Art Department Coordinator |
| Stephan O. Gessler | Assistant Art Director |
| Emmanuel Shiu | Conceptual Design |
| Friederike Beckert | Greensman |
| Mathias Braun | Location Scout |
| Michael Finlay | Painter |
| Jeff Yagher | Sculptor |
| Anja Müller | Set Designer |
| Enzo Enzel | Standby Painter |
| Sebastian Meuschel | Camera Operator |
| Christian Almesberger | First Assistant Camera |
| Dieter Bähr | Key Grip |
| Mario Grech | Grip |
| John Trapman | Aerial Director of Photography |
| Florian Emmerich | Steadicam Operator |
| Jasin Boland | Still Photographer |
| Alexis Scott | Assistant Costume Designer |
| Carola Raum | Costume Supervisor |
| Enzo Angileri | Hair Designer |
| Björn Rehbein | Hairstylist |
| Jane O'Kane | Key Hair Stylist |
| Anita Brolly | Makeup Artist |
| Denise Kum | Makeup Designer |
| Natalie Weber | Seamstress |
| Dietke Brandt | Set Costumer |
| Robert Bunge | Carpenter |
| Shadi Almassizadeh | CG Supervisor |
| Howard Samuelsohn | Dialect Coach |
| Bobby Finn | Driver |
| Kiki Morris | Post Production Supervisor |
| Alex Matcham | Production Controller |
| Gerold Bublak | Propmaker |
| Marcus Haendgen | Property Master |
| Diana K. Brandt | Security |
| Kathleen Rodriguez | Set Production Assistant |
| Claudine Biswas-MacKenzie | Stand In |
| Charles Croughwell | Stunt Coordinator |
| Kevin Abercrombie | Stunts |
| Tom Trafalski | Temp Music Editor |
| Philipp Klausing | Transportation Captain |
| Oliver Kueper-Grobecker | Transportation Coordinator |
| Michael Scheel | Unit Production Manager |
| Jeanmarie Murphy-Burke | Unit Publicist |
| Carrie Cassada | Visual Effects Editor |
| Lisa C. Satriano | First Assistant Director |
| Trudy Ramirez | Script Supervisor |
| Michael Hatzer | Color Timer |
| Simon Coke | Dialogue Editor |
| Bergit Angermeier | Editorial Production Assistant |
| Gershon Hinkson | First Assistant Editor |
| Rene Frommholz | Best Boy Electric |
| Matthias Dippe | Electrician |
| Martin Frank | Gaffer |
| Ron Rakowski | Rigging Gaffer |
| Anja Dihrberg | Casting Associate |
| Mathias Braun | Location Manager |
| Christopher Abeyta | Production Accountant |
| Wendy Cox | Production Coordinator |
| Miki Emmrich | Production Manager |
| Hadon Install | Boom Operator |
| Christopher Alba | Assistant Sound Editor |
| Valerie Davidson | Foley Editor |
| Tommy Lockett | Music Editor |
| Dominik Hauser | Orchestrator |
| Bill R. Dean | Sound Effects Editor |
| Manfred Banach | Sound Mixer |
| Richard Adrian | Supervising Sound Editor |
| Michael Adkisson | Digital Compositors |
| Gerd Nefzer | Special Effects Supervisor |
| Lori Green | Visual Effects |
| Bryce Brecheisen | Visual Effects Coordinator |
| Sarah Coatts | Visual Effects Producer |
| Syd Dutton | Visual Effects Supervisor |
| Bryan Pennington | Dolby Consultant |
| Daniel Mattig | Unit Manager |
| Gabriele Hans | Costume Assistant |
| Lyda Blank | Second Assistant Director |
| Ralph Eisenmann | Second Second Assistant Director |
| Charles Croughwell | Second Unit Director |
| Julie Cummings | Third Assistant Director |
| Steffi Kulse | Construction Buyer |
| Christian Ehlert | Lead Set Dresser |
| Chris Kunzmann | Special Props |
| Robin Richesson | Storyboard Artist |
| Francine Lecoultre | Textile Artist |
| Garson Yu | Title Designer |
| Petra Bach | ADR Editor |
| Doc Kane | ADR Mixer |
| Julie Altus | ADR Recordist |
| Robin Harlan | Foley Artist |
| Randy Singer | Foley Mixer |
| Hugh Waddell | Supervising ADR Editor |
| Frank Smathers | Supervising Dialogue Editor |
| Antje Blümel | Special Effects Assistant |
| Thomas Friedrichs | Special Effects Technician |
| Andrew Edwards | VFX Artist |
| Adam Lisagor | Visual Effects Compositor |
| Ryan Stafford | Visual Effects Production Manager |
| Johnny Feurer | Assistant Camera |
| Glenn König | Best Boy Grip |
| Nadine Neuneier | Camera Loader |
| Ole Thomas | Camera Trainee |
| Jan Brun | Dolly Grip |
| Viviane Bendjus | Second Assistant Camera |
| Josh Kent | CG Animator |
| Gary Abrahamian | Lead Animator |
| Bernd Angerer | Senior Animator |
| Rori Bergman | Casting Assistant |
| Daniela Backes | Wardrobe Assistant |
| Ray Boniker | Assistant Editor |
| N. Bantu Key | Digital Colorist |
| Ryan Helsley | Digital Intermediate Assistant |
| J.W. Kompare | Digital Intermediate Editor |
| René Frotscher | Location Assistant |
| Nina Hueskes | Location Coordinator |
| Philipp Abel | Location Production Assistant |
| Tim Simonec | Conductor |
| Boris Elkis | Music Programmer |
| Lora Marie Taylor | Accountant |
| Vladimir Fuentes | Assistant Accountant |
| Silvia Lindner | Assistant Production Coordinator |
| Paul A. Davies | CG Artist |
| Sonja Burchard | Compositing Supervisor |
| Lisa Spence | Digital Effects Producer |
| Marcel Dykiert | Extras Casting |
| Michael Vasquez | First Assistant Accountant |
| Tim Dobbert | Matchmove Supervisor |
| Caroleen Green | Matte Painter |
| Angela Randazzo | Payroll Accountant |
| Carsten Woithe | Pre-Visualization Supervisor |
| Toni-Maria Anschütz | Production Assistant |
| Stephan Arendt | Production Driver |
| Stephen Emery | Production Executive |
| Ana Keil | Production Secretary |
| Pallavi Devabhaktuni | Rotoscoping Artist |
| Manny Chavez | Stunts |
| Mark Ginther | Stunts |
| Sascha Girndt | Stunts |
| Sean Graham | Stunts |
| Tabby Hanson | Stunts |
| Udo Harnach | Stunts |
| Alisa Hensley | Stunts |
| Daniel T. O'Brien | Stunts |
| Chase Penny | Stunts |
| Vicki Phillips | Stunts |
| Mika Saito | Stunts |
| Armin Sauer | Stunts |
| Petra Sprecher | Stunts |
| Scott Sproule | Stunts |
| Wolfgang Stegemann | Stunts |
| Andreas Tietz | Stunts |
| Vanessa Wieduwilt | Stunts |
| Alexander Witt | Second Unit Director |
| Mario Migge | Boom Operator |
| İlker Çatak | Production Assistant |
