 | Sandra Bullock als Lucy Eleanor Moderatz |
 | Bill Pullman als Jack Callaghan |
 | Peter Gallagher als Peter Callaghan |
 | Peter Boyle als Ox Callaghan |
 | Jack Warden als Saul |
 | Glynis Johns als Elsie |
 | Micole Mercurio als Midge Callaghan |
 | Jason Bernard als Jerry |
 | Michael Rispoli als Joe Jr. |
 | Ally Walker als Ashley Bacon |
 | Monica Keena als Mary Callaghan |
 | Ruth Rudnick als Wanda |
 | Marcia Wright als Celeste |
 | Dick Cusack als Dr. Rubin |
| Thomas Q. Morris als Man in Peter's Room |
| Bernie Landis als Doorman |
 | James Krag als Dalton Clarke |
 | Rick Worthy als Orderly |
 | Marc Grapey als Intern |
 | Joel Hatch als Priest |
 | Mike Bacarella als Mr. Fusco |
 | Peter Siragusa als Hot Dog Vendor |
 | Gene Janson als Man in Church |
 | Krista Lally als Phyllis |
 | Kevin Gudahl als Cop at ICU |
 | Ann Whitney als Blood Donor Nurse |
 | Margaret Travolta als Admitting Nurse |
 | Shea Farrell als Ashley's Husband |
 | Kate Reinders als Beth |
| Susan Messing als Celeste's Friend |
 | Richard Pickren als Lucy's Father |
| Megan Schaiper als Young Lucy |
| Phedon Papamichael | Director of Photography |
| Wally Pfister | Camera Operator |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Roger Birnbaum | Producer |
| Randy Edelman | Original Music Composer |
| Jon Turteltaub | Director |
| Bruce Green | Editor |
| Steve Barron | Executive Producer |
| Daniel G. Sullivan | Screenplay |
| Fredric LeBow | Screenplay |
| Joe Roth | Producer |
| Jonathan Glickman | Associate Producer |
| Arthur M. Sarkissian | Executive Producer |
| Larry Dias | Set Decoration |
| David Rennie | First Assistant Editor |
| Daniel B. Clancy | Leadman |
| Ralph Ferraro | Orchestrator |
| Betsy Cox | Costume Design |
| Paul Massey | Sound Re-Recording Mixer |
| Charles J.D. Schlissel | Unit Production Manager |
| Charles J.D. Schlissel | Co-Producer |
| Harry N. Haase | Lead Painter |
| Rafael E. Sánchez | Gaffer |
| Bruce Franklin | First Assistant Director |
| Amelia Hochberg | Assistant Set Decoration |
| Garreth Stover | Production Design |
| Chris Cornwell | Art Direction |
| Adam Sawelson | Dialogue Editor |
| James Beshears | ADR Supervisor |
| Chris David | Sound Re-Recording Mixer |
| David Orr | Color Timer |
| Carl Paoli | Stunts |
| Elaina P. Schulman | Key Hair Stylist |
| Suzan Wexler | Set Designer |
| Marcie Friedman | Art Department Coordinator |
| Alphonse Blumenthal | Best Boy Electric |
| Peter Kuttner | First Assistant Camera |
| Deborah K. Dee | Hairstylist |
| Rick LeFevour | Stunt Coordinator |
| Kimberly Guenther Durkin | Costume Supervisor |
| Blair Scheller | Boom Operator |
| Blair Scheller | Utility Sound |
| Alicia Accardo | Script Supervisor |
| Gary Mundheim | Foley Editor |
| J. Paul Huntsman | Supervising Sound Editor |
| Benjamin Beardwood | Dialogue Editor |
| Don J. Hug | Location Manager |
| Bruce Tanis | Sound Effects Editor |
| Katherine E. Beyda | Production Supervisor |
| Dennis S. Sands | Scoring Mixer |
| Tyler Osman | Construction Coordinator |
| Whitney James | Makeup Artist |
| John LaSalandra | Music Editor |
| Jeff Rosen | Foley Supervisor |
| Eugene F. Crededio | Gaffer |
| Elizabeth Lang | Casting Associate |
| Pamela S. Westmore | Makeup Supervisor |
| Timothy J. Maxwell | Transportation Captain |
| Leslie Mikol | Production Assistant |
| Heather Pollock | Costumer |
| John P. Friday | Electrician |
| Robert Krzeminski | Grip |
| Guy Clayton | Special Effects Coordinator |
| Gary Lewis | Dialogue Editor |
| James Hogan | Transportation Captain |
| Jeffrey A. Williams | Boom Operator |
| Joe Earle | Sound Effects Editor |
| Dean Drabin | Foley Mixer |
| Morgan Michael Lewis | Key Grip |
| Wileen Dragovan | Assistant Location Manager |
| Robert Dawson | Title Designer |
| George DiLeonardi | Transportation Coordinator |
| Michael P. Weinstein | Still Photographer |
| Curt Frisk | Production Sound Mixer |
| Anthony J. Lullo | Electrician |
| Hope A. Nielsen | Second Assistant Camera |
| Rick Boynton | Locale Casting Director |
| Sam Bertone | Electrician |
| Jeanine Payne | First Assistant Sound Editor |
| Chris Freres | Best Boy Grip |
| Stephen Janisz | ADR Editor |
| William D'Ambra | Property Master |
| David J. Chamerski | Assistant Property Master |
| James Fierro | Stunts |
| Ann Hadsell | Foley Recordist |
| Theresa Repola Mohammed | Negative Cutter |
| Mark Purkart | Grip |
| Fernando M. Briones | Grip |
| Dana Armonda | Production Secretary |
| Linda Perlin | Stunts |
| Frank Yario Jr. | Video Assist Operator |
| John S. Robertson | Rigging Grip |
| John Hudecek | Dolly Grip |
| Elaine Johnson | Associate Producer |
| Susan Stremple | Co-Producer |
| Stephan Choiniere | Stunts |
| Sandra M. Middleton | Second Assistant Director |
| Aiman A. Humaideh | Second Second Assistant Director |
| Kaye Nottbusch | Set Costumer |
| Rebecca Nicolaou | Assistant Sound Editor |
| Melissa K. Cooper | Production Coordinator |
| Rosemary Orlando | Assistant Production Coordinator |
| Peter Hollocker | Production Assistant |
| Julie Herman | Production Assistant |
| Gerald F. Nichols | Production Assistant |
| Mary Mooney | Producer's Assistant |
| Mark H. Brunetz | Actor's Assistant |
| Robin E. Agron | Assistant Location Manager |
| Jack W. Haddox | Production Accountant |
| Patricia J. Amaral | First Assistant Accountant |
| Cheryl McHugh | Assistant Accountant |
| Patricia S. Kingery | Assistant Accountant |
| Braden Wright | Unit Publicist |
| Sidney Edwards | Technical Advisor |
