 | Robert De Niro als The Creature / Sharp Featured Man |
 | Kenneth Branagh als Victor Frankenstein |
 | Tom Hulce als Henry Clerval |
 | Helena Bonham Carter als Elizabeth |
 | Aidan Quinn als Cap. Robert Walton |
 | Ian Holm als Baron Frankenstein |
 | Richard Briers als Grandfather |
 | John Cleese als Prof. Waldman |
 | Robert Hardy als Prof. Krempe |
 | Cherie Lunghi als Caroline Beaufort Frankenstein |
 | Celia Imrie als Mrs. Moritz |
 | Trevyn McDowell als Justine |
 | Mark Hadfield als Felix |
 | Gerard Horan als Claude |
| Joanna Roth als Marie |
| Alfred Bell als Landlord |
| Sasha Hanau als Maggie |
| Joseph England als Thomas |
 | Richard Clifford als Minister |
 | George Asprey als Policeman |
 | Hugh Bonneville als Schiller |
 | Ryan J-W Smith als William |
| Charles Wyn-Davies als Young William |
 | Rory Jennings als Young Victor |
| Christina Cuttall als Young Justine |
 | Hannah Taylor-Gordon als Young Elizabeth |
| Susan Field als Frau Brach |
 | Jimmy Yuill als Greigori |
| Chris Barnes als Ship's Crew |
 | Shaun Prendergast als Ship's Crew |
| Tommy Wright als Ship's Crew |
 | David Kennedy als Ship's Crew |
| Paul Gregory als Ship's Crew |
| Chris Hollis als Ship's Crew |
| Robin Lloyd als Ship's Crew |
 | Alex Lowe als Ship's Crew |
| Graham Loughridge als Ship's Crew |
| Simon Cox als Ship's Crew |
| Robert Hines als Ship's Crew |
| Lonnie James als Rough Woman |
 | Jenny Galloway als Vendor's Wife |
 | Peter Jonfield als Rough Man |
 | Edward Jewesbury als City Official |
 | Siobhan Redmond als Midwife |
| Francine Morgan als Assistant Midwife |
| Sue Long als Woman in Labor |
 | Michael Gould als Stablehand |
 | Angus Wright als Guard |
| Max Gold als Servant |
| Abigail Reynolds als Mansion Staff |
| Theresa Fresson als Mansion Staff |
| Mark Inman als Mansion Staff |
| Dudi Appleton als Mansion Staff |
| Meriel Schofield als Mansion Staff |
 | Jim Carter als Executioner (uncredited) |
| Mary Shelley | Novel |
| Desmond Crowe | Art Direction |
| John Fenner | Art Direction |
| John Veitch | Producer |
| Francis Ford Coppola | Producer |
| Priscilla John | Casting |
| James Acheson | Costume Design |
| Andrew Marcus | Editor |
| Kenneth Branagh | Director |
| James V. Hart | Producer |
| Patrick Doyle | Original Music Composer |
| Roger Pratt | Director of Photography |
| Tim Harvey | Production Design |
| Jeff Kleeman | Associate Producer |
| Campbell Askew | Supervising Sound Editor |
| Colin Miller | Sound Effects Editor |
| Robin O'Donoghue | Sound Re-Recording Mixer |
| Martin Childs | Supervising Art Director |
| Dominic Lester | Sound Re-Recording Mixer |
| Carol Hemming | Makeup Artist |
| Robert De Niro | Associate Producer |
| Kenneth Branagh | Co-Producer |
| Fred Fuchs | Executive Producer |
| Paul Engelen | Makeup Artist |
| David Parfitt | Co-Producer |
| Daniel Parker | Makeup Artist |
| David Appleby | Still Photographer |
| Pauline Griffith | Foley Artist |
| Chuck Finch | Gaffer |
| Richard Hooper | Armorer |
| Ivan Sharrock | Sound Mixer |
| Robert Palmer | Second Assistant Camera |
| Bruce Bigg | Property Master |
| Neil Lamont | Assistant Art Director |
| Allan Moss | Sculptor |
| Graham Sutton | Foley Editor |
| Michael Trent | Assistant Sound Editor |
| Barbra Flinder | Title Designer |
| Carol Hemming | Hair Designer |
| Peter Francis | Set Designer |
| William Trent | Dialogue Editor |
| Peter Robertson | Steadicam Operator |
| Steven Lawrence | Assistant Art Director |
| Michael Redding | Construction Coordinator |
| Simon Crane | Stunt Coordinator |
| Maggie Rodford | Music Supervisor |
| Ben Howarth | Third Assistant Director |
| John Payne | Dolly Grip |
| Stuart Hopps | Choreographer |
| Gavin Gordon | Carpenter |
| Robert Gavin | Dialogue Editor |
| Sean McCabe | Stunt Double |
| Annie Penn | Script Supervisor |
| Mark Coulier | Prosthetic Makeup Artist |
| Bernard Bellew | Second Assistant Director |
| Tracey Eddon | Stunt Double |
| Doug Bishop | Scenic Artist |
| Tom Meadows | Sound Mixer |
| Graeme Crowther | Stunt Double |
| Roger Lanser | Second Unit Director of Photography |
| Kate Robinson | Steadicam Operator |
| Paolo Mantini | Key Hair Stylist |
| Sallie Hard | Third Assistant Director |
| Andrew Marcus | Second Unit Director |
| Sarah Franzl | Stunts |
| Simon Hume | First Assistant Camera |
| Billy Merrell | Best Boy Electric |
| Roy Prendergast | Supervising Music Editor |
| Brian Bishop | Scenic Artist |
| David Snell | Conductor |
| John Bateman | Foley Mixer |
| Gerard McCann | Music Editor |
| Julia Wilson Dickson | Dialogue Coach |
| Simon Moseley | Second Assistant Director |
| Mark Sale | Assistant Dialogue Editor |
| Ricky Butt | Foley Artist |
| Deborah Lanser | Makeup Artist |
| Christopher Newman | Assistant Director |
| Jonathan McKinstry | Assistant Art Director |
| Jenny Lee Wright | Foley Artist |
| Nick Penn | First Assistant Camera |
| Richard Pointing | Costume Supervisor |
| Betty Glasow | Hairstylist |
| Ken Pattenden | Construction Manager |
| Mike Dowson | ADR & Dubbing |
| Lawrence Ashmore | Orchestrator |
| Frank Darabont | Writer |
| Steph Lady | Writer |
