 | Milo Ventimiglia als Ted Grey |
 | Alyssa Milano als Gwen Williamson |
 | Michael Weston als Jake Gallo |
 | Lauren Lee Smith als Juliette Bath |
 | Johnny Whitworth als Griffin Cavenaugh |
 | John de Lancie als Dr. Quentin Morris |
 | Meiling Melançon als Catherine Ivy |
 | Keir O'Donnell als Ben Stravinsky |
 | Buddy Lewis als Harper Johnson |
 | Dan Callahan als Chip Bentwood |
 | Larry Drake als Fat Bastard |
 | Med Abrous als Young Pathology Resident |
 | Alan Blumenfeld als Mr. Williamson |
 | Gary Buckner als Motherfucker |
 | Jeb Burris als Worker |
| Eurydice Davis als Hooker |
 | Jarvis W. George als ICU Doctor |
| Anne Girard als Donna |
| Eric Kaldor als Homeless Lunatic |
| Keith Morris als Hitchhiker |
| Kate Mulligan als Woman on Bus |
 | Donnie Smith als Man on Bus |
| Yvonne Mojica-Nelson als Hispanic ICU Nurse |
 | Debbie Pollack als Mrs. Williamson |
| Cheryl Starbuck als Panicked Woman |
 | Sam Witwer als Party Boy |
 | Brett Kelly als Dead Kid |
 | Eddie Mariano als Hospital Visitor |
| Waneeki Yokomee-Fung als Visitor |
| Marc Schölermann | Director |
| Mark Neveldine | Screenplay |
| Johannes Kobilke | Original Music Composer |
| Ekkehart Pollack | Director of Photography |
| Todd E. Miller | Editor |
| Jerry Fleming | Production Design |
| Brian Taylor | Screenplay |
| Marcus Gilbert | Producer |
| Gary Lucchesi | Producer |
| Mark Neveldine | Producer |
| Tom Rosenberg | Producer |
| Nancy Nayor | Casting |
| Kelly Wagner | Casting |
| Frank Helmer | Costume Design |
| Randy Westgate | Makeup Department Head |
| Talon McKenna | Art Direction |
| Betty Berberian | Set Decoration |
| Calvin Scott | Makeup Artist |
| Sara De Pue | Makeup Artist |
| Dugg Kirkpatrick | Hairstylist |
| Ken Niederbaumer | Makeup Effects |
| Mark Shoaf | CG Supervisor |
| Cheryl Starbuck | Script Supervisor |
| Alfredo Rosado | Additional Photography |
| Andrew Robison | Best Boy Grip |
| Zoe Aimee Zaitzeff | Camera Production Assistant |
| Matthew Kistenmacher | Electrician |
| Aaron Schulte | Electrician |
| Grg Magidow | First Assistant "A" Camera |
| Penny Sprague | First Assistant "B" Camera |
| Justin Duval | Gaffer |
| Jonathan Cushing | Grip |
| Bryan Gilbert | Grip |
| Leo Ibanez | Grip |
| Alpheus Underhill | Grip |
| Phillip Miller | Key Grip |
| Paul Lambiase | Key Rigging Grip |
| Wayne Swab | Rigging Gaffer |
| Lisa Bonaccorso | Second Assistant Camera |
| David F. Clark | Second Assistant Camera |
| Saeed Adyani | Still Photographer |
| Wendy Means | Art Department Coordinator |
| Wayne Springfield | Construction Coordinator |
| Trey Shaffer | Graphic Designer |
| John A. Gomez | Leadman |
| David Lombard | Leadman |
| Jerry A. Chavez | Property Master |
| Creighton Larson | Propmaker |
| Shant Balkian | Set Dresser |
| Jesse Harris | Set Dresser |
| John Fox | Storyboard Artist |
| Tracey Anderson | Assistant Makeup Artist |
| Sarah Ault | Hairstylist |
| Richard De Alba | Hairstylist |
| Calvin Scott | Key Makeup Artist |
| Nicole Leitner | Costume Assistant |
| Michelle Pershing | Costume Supervisor |
| Emily Dominguez | Costumer |
| Melissa Montague | Costumer |
| Chantal Nightingale Thomas | Costumer |
| Danielle Baker | Set Costumer |
| Alan Freedman | ADR Mixer |
| Eric Thompson | ADR Mixer |
| Mark F. Dennett | Boom Operator |
| James Bailey | Foley Artist |
| Geordy Sincavage | Foley Mixer |
| Rachel Holley | Sound Editor |
| Aynee Osborn | Sound Editor |
| Melissa A. Corns | Sound Effects Editor |
| Justin Herman | Sound Mix Technician |
| Jared Marshack | Sound Mix Technician |
| Mary Jo Devenney | Sound Mixer |
| Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Gary Gegan | Sound Re-Recording Mixer |
| Kelly Cabral | Supervising Sound Editor |
| Dominika Posserén | Casting Associate |
| Valance Eisleben | Digital Conform Editor |
| Mike Sowa | Digital Intermediate Colorist |
| Ryan Helsley | Digital Intermediate Producer |
| Jim Schulte | First Assistant Editor |
| Michael G. Cruz | Assistant Location Manager |
| Leif Tilden | Assistant Location Manager |
| Andrew C. Keeter | Location Manager |
| Kimmin O'Donnell | Digital Compositor |
| Donnie Creighton | Digital Intermediate Producer |
| Andrew Byrne | Visual Effects |
| Sk Nguyen | Visual Effects Coordinator |
| Migs Rustia | Visual Effects Editor |
| Paul Stemmer | Visual Effects Editor |
| Les G. Jones | Visual Effects Producer |
| Gary Oldroyd | Visual Effects Producer |
| Tiffany Smith | Visual Effects Producer |
| Tracy Takahashi | Visual Effects Producer |
| James McQuaide | Visual Effects Supervisor |
| Mark R. Byers | Special Effects Coordinator |
| Tom von Badinski | Special Effects |
| Brendan Early | Assistant Production Coordinator |
| Tanoa Parks | Production Accountant |
| Stephen Clarke | Production Assistant |
| Sophia Lucchesi | Production Assistant |
| Jannie Penvari | Production Assistant |
| Renee Henry | Production Assistant |
| Alex L. Worman | Unit Publicist |
| Eric Craig | Music Supervisor |
| Brian McNelis | Music Supervisor |
| Marc Bienstock | Executive Producer |
| Phyllis Carlyle | Executive Producer |
| Yan Fisher-Romanovsky | Executive Producer |
| Eric Reid | Executive Producer |
| David Scott Rubin | Executive Producer |
| Barrett Stuart | Executive Producer |
| Brian Taylor | Producer |
| Skip Williamson | Producer |
| Richard S. Wright | Producer |
| Marc Bienstock | Unit Production Manager |
| Tony Gittelson | First Assistant Director |
| Rip Murray | First Assistant Director |
| Darrin Prescott | Stunt Coordinator |
| Jon H. Epstein | Stunt Coordinator |
| Chris O'Hara | Stunt Coordinator |
| Kenneth Burke | Production Supervisor |
| Andy Shuttleworth | Steadicam Operator |
| Chris Gehrt | Casting Assistant |
| Lance Gilbert | Utility Stunts |
| Chris Palermo | Stunt Double |
| David Kramer | Extras Casting |
| Paul E. Short | Utility Stunts |
| Tanoai Reed | Utility Stunts |
| Jeremy Fry | Stunt Double |
