 | Jamie Foxx als Joe Gardner (voice) |
 | Tina Fey als 22 (voice) |
 | Graham Norton als Moonwind (voice) |
 | Rachel House als Terry (voice) |
 | Alice Braga als Counselor Jerry (voice) |
 | Richard Ayoade als Counselor Jerry (voice) |
 | Phylicia Rashād als Libba Gardner (voice) |
 | Donnell Rawlings als Dez (voice) |
 | Ahmir-Khalib Thompson als Curly (voice) |
 | Angela Bassett als Dorothea (voice) |
 | Cora Champommier als Connie (voice) |
 | Margo Hall als Melba (voice) |
 | Daveed Diggs als Paul (voice) |
 | Rhodessa Jones als Lulu (voice) |
 | Wes Studi als Counselor Jerry (voice) |
 | Sakina Jaffrey als Doctor (voice) |
 | Fortune Feimster als Counselor Jerry (voice) |
 | Calum Grant als Hedge Fund Manager (voice) |
 | Laura Mooney als Therapy Cat Lady (voice) |
| Peggy Flood als Marge (voice) |
 | Zenobia Shroff als Counselor Jerry (voice) |
 | June Squibb als Gerel (voice) |
| Ochuwa Oghie als Dancerstar (voice) |
 | Jeannie Tirado als Principal Arroyo (voice) |
 | Cathy Cavadini als Dreamerwind (voice) |
 | Dorian Lockett als Dorian (voice) |
| Doris Burke als Basketball Announcer (voice) |
 | Ronnie del Carmen als Windstar (voice) |
| Esther K. Chae als Miho (voice) |
 | Élisapie als Miali (voice) |
| Marcus Shelby als Ray Gardner (voice) |
| Trent Reznor | Original Music Composer |
| Ren Klyce | Sound Designer |
| Ren Klyce | Supervising Sound Editor |
| Ren Klyce | Sound Re-Recording Mixer |
| Bobby Podesta | Animation Supervisor |
| Dee Selby | Foley Editor |
| Steve Pilcher | Production Design |
| Pete Docter | Screenplay |
| Pete Docter | Director |
| Pete Docter | Story |
| Scott Curtis | Foley Mixer |
| Kevin Reher | Casting |
| Shelley Roden | Foley Artist |
| Atticus Ross | Original Music Composer |
| Dan Scanlon | Executive Producer |
| John Mulaney | Thanks |
| Natalie Lyon | Casting |
| John Roesch | Foley Artist |
| Michael Yates | Story Artist |
| Cheryl Nardi | ADR Supervisor |
| David Parker | Sound Re-Recording Mixer |
| Jonathon Stevens | Sound Effects Editor |
| Kristen Lester | Story Supervisor |
| Steve Orlando | Sound Effects Editor |
| Justin Pearson | Sound Editor |
| Justin Pearson | Music Editor |
| Thom Brennan | Foley Supervisor |
| Jon Batiste | Original Music Composer |
| Kevin Nolting | Editor |
| Sally Boldt | Music Editor |
| Ian Megibben | Director of Photography |
| Matt Aspbury | Director of Photography |
| Kiri Hart | Executive Producer |
| Jessica Heidt | Script Supervisor |
| Kimberly Patrick | Sound Effects Editor |
| Michael Fong | Visual Effects Supervisor |
| Dana Murray | Producer |
| Coya Elliott | Supervising Sound Editor |
| Jude Brownbill | Animation Supervisor |
| Jaclyn Simon | Production Manager |
| Michael Warch | Associate Producer |
| Nathan Nance | Additional Sound Re-Recording Mixer |
| Eric M. Barker | First Assistant Editor |
| Aphton Corbin | Story Artist |
| Kemp Powers | Screenplay |
| Kemp Powers | Story |
| Kemp Powers | Co-Director |
| Kate Hansen-Birnbaum | Casting Associate |
| Mike Jones | Screenplay |
| Mike Jones | Story |
| Paige Johnstone | Script Coordinator |
| Rebecca Euphrat | Animation Manager |
| Grace Geller | Lighting Coordinator |
| Jeanette Elizabeth Mckillop | Lighting Coordinator |
