 | John Lithgow als Carter Nix / Cain / Dr. Nix / Josh / Margo |
 | Lolita Davidovich als Jenny O'Keefe Nix |
 | Steven Bauer als Jack Dante |
 | Frances Sternhagen als Dr. Lynn Waldheim |
 | Gregg Henry als Lt. Terri |
 | Tom Bower als Sgt, Cully |
 | Mel Harris als Sarah |
 | Teri Austin als Karen Bowman |
 | Gabrielle Carteris als Nan |
 | Barton Heyman als Mack |
 | Amanda Pombo als Amy Nix |
| Kathleen Callan als Emma Dante |
| Ed Hooks als Coroner |
 | Karen Kahn als Saleslady |
| Noe Montoya als Gardener |
| Riq Boogie Espinoza als Gardener |
| Carolyn Morrell als Newscaster |
| W. Allen Taylor als Peters |
| Scott Townley als Little Boy (Josh) |
| Mary Uhland als Receptionist |
| Steve Schill als Weatherman |
 | James Van Harper als Young Detective |
| Brian De Palma | Director |
| Robert Dalva | Editor |
| Stephen H. Burum | Director of Photography |
| Bonnie Koehler | Editor |
| Brian De Palma | Screenplay |
| Pino Donaggio | Original Music Composer |
| Gale Anne Hurd | Producer |
| Paul Hirsch | Editor |
| Doug Kraner | Production Design |
| Robbie Knott | Special Effects Coordinator |
| J. Michael Muro | Steadicam Operator |
| Emanuel Millar | Hairstylist |
| Pam Dixon | Casting |
| Kristen Ross | Art Department Coordinator |
| Carol DePasquale | Script Supervisor |
| Mark Billerman | Art Direction |
| Larry McConkey | Steadicam Operator |
| Frank Fitzpatrick | Music Supervisor |
| Dustin Blauvelt | Camera Operator |
| Barbara Munch | Set Decoration |
| Phil Bray | Still Photographer |
| Bobbie Read | Costume Design |
| James Dyer | Assistant Director |
| Spiro Razatos | Stunts |
| Glory Fioramonti | Stunts |
| Thomas Floutz | Special Effects Makeup Artist |
| Michael R. Joyce | Co-Producer |
| Don W. Wegner | Set Designer |
| J. Michael Davis | Set Dresser |
| James Ashwill | Foley Mixer |
| Susan Dudeck | ADR Supervisor |
| Allan Bond | ADR Recordist |
| Nerses Gezalyan | Foley Recordist |
| Rick Kline | Sound Re-Recording Mixer |
| John Morris | Supervising Sound Editor |
| Dan O'Connell | Foley Artist |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Greg Orloff | Foley Mixer |
| Mark Pappas | Foley Editor |
| Rodger Pardee | Sound Effects Editor |
| Steve Richardson | Foley Editor |
| Charleen Richards-Steeves | ADR Mixer |
| Jerry Ross | Supervising Sound Editor |
| Alicia Stevenson | Foley Artist |
| Gary Hymes | Stunt Coordinator |
| Myke Schwartz | Stunts |
| Fred Waugh | Stunts |
| Don L. Henderson | Grip |
