 | Keith Ferguson als Megamind (voice) |
 | Laura Post als Roxanne Ritchi (voice) |
 | Josh Brener als OI' Chum (voice) |
 | Maya Tuttle als Keiko Morita (voice) |
 | Emily Tuñon als Lady Doppler (voice) |
 | Talon Warburton als Lord Nighty-Knight (voice) |
 | Scott Adsit als Pierre Pressure (voice) |
 | Chris Sullivan als Behemoth (voice) |
 | Tony Hale als Mel / Mr. Donut / TV Announcer (voice) |
 | Adam Lambert als Machiavillain (voice) |
 | Jeanine Mason als Christina Christo / Hostess (voice) |
 | Michael Beattie als Eccentric Eddie (voice) |
 | Eric Fogel als Polly 227 (voice) |
 | Todd Haberkorn als Big King Fish (voice) |
 | Eric Murphy als Blue Mackerel (voice) |
 | Joey Rudman als Red Snapper (voice) |
 | Roger Craig Smith als Mayor (voice) |
 | Carlos Alazraqui als Additional Voices (voice) |
 | Eric Bauza als Additional Voices (voice) |
 | Kimberly Brooks als Additional Voices (voice) |
| J.D. Ryznar | Co-Executive Producer |
| Alan Schoolcraft | Executive Producer |
| Brent Simons | Executive Producer |
| Eric Fogel | Director |
| Brent Simons | Writer |
| Alan Schoolcraft | Writer |
| Ania O'Hare | Casting |
| Katie Galvan | Casting |
| Dennis Crawford | Storyboard Artist |
| Solomon Fong | Storyboard Artist |
| Jason Horychun | Storyboard Artist |
| Renee Howerton | Storyboard Artist |
| Hadas Rosen | Storyboard Artist |
| Alejandra Wiechers | Storyboard Artist |
| Jessica Bulinski | Art Direction |
| Karen Poon | Art Direction |
| Nora Lewis-Borbely | Line Producer |
| Michael Moragne | Line Producer |
| Sarah Wall | Line Producer |
| Eric Fogel | Executive Producer |
| Jeff Solway | Character Designer |
| Mariel Abella | Prop Designer |
| Rod Filbrandt | Prop Designer |
| Stephanie Foley | Prop Designer |
| Amy Fielder | Background Designer |
| Nicola Kwit | Background Designer |
| Gareth Sharples | Background Designer |
| Stacey Chomiak | Color Designer |
| Allyssa Clemente | Color Designer |
| Margot Senchyna | Matte Painter |
| Marcel Duperreault | Sound Re-Recording Mixer |
| Todd Araki | Sound Editor |
| Jason Fredrickson | Sound Editor |
| Kirk Furniss | Sound Editor |
| Adam McGhie | Foley Artist |
| Peter Cacioppo | Executive In Charge Of Production |
| Gregg Goldin | Executive In Charge Of Production |
| David Wiebe | Executive In Charge Of Production |
| Matthew Janszen | Original Music Composer |
| Bryan Winslow | Original Music Composer |
| Vivian Aguiar-Buff | Music Supervisor |
| Lauren Vogel | Music Supervisor |
| Alex Seaver | Main Title Theme Composer |
