 | Jodie Foster als Clarice M. Starling |
 | Anthony Hopkins als Dr. Hannibal Lecter |
 | Scott Glenn als Jack Crawford |
 | Ted Levine als Jame 'Buffalo Bill' Gumb |
 | Anthony Heald als Dr. Frederick Chilton |
 | Brooke Smith als Catherine Martin |
 | Diane Baker als Senator Ruth Martin |
 | Kasi Lemmons als Ardelia Mapp |
 | Frankie Faison als Barney Matthews |
 | Tracey Walter als Lamar |
 | Charles Napier als Lt. Boyle |
 | Danny Darst als Sgt. Tate |
 | Alex Coleman als Sgt. Jim Pembry |
 | Dan Butler als Roden |
 | Paul Lazar als Pilcher |
 | Ron Vawter als Paul Krendler |
 | Roger Corman als FBI Director Hayden Burke |
| Lawrence A. Bonney als FBI Instructor |
 | Lawrence T. Wrentz als Agent Burroughs |
| Don Brockett als Friendly Psychopath |
| Frank Seals Jr. als Brooding Psychopath |
 | Stuart Rudin als Miggs |
| Jeffrie Lane als Clarice's Father |
| Leib Lensky als Mr. Lang |
| George 'Red' Schwartz als Mr. Lang's Driver |
| Jim Roche als TV Evangelist |
| James B. Howard als Boxing Instructor |
| Bill Miller als Mr. Brigham |
| Chuck Aber als Agent Terry |
| Gene Borkan als Oscar |
 | Pat McNamara als Sheriff Perkins |
 | Kenneth Utt als Dr. Akin |
| Adelle Lutz als TV Anchor Woman |
 | Obba Babatundé als TV Anchor Man |
| Jim Dratfield als Sen. Martin's Aide |
| Stanton-Miranda als 1st Reporter |
| Rebecca Saxon als 2nd Reporter |
 | Cynthia Ettinger als Officer Jacobs |
 | Brent Hinkley als Officer Murray |
| Steve Wyatt als Airport Flirt |
 | David Early als Spooked Memphis Cop |
 | Andre B. Blake als Tall Memphis Cop |
| Bill Dalzell als Distraught Memphis Cop |
 | Chris Isaak als SWAT Commander |
 | Daniel von Bargen als SWAT Communicator |
| Tommy Lafitte als SWAT Shooter |
| Josh Broder als EMS Attendant |
| Buzz Kilman als EMS Driver |
 | Harry Northup als Mr. Bimmel |
 | Lauren Roselli als Stacy Hubka |
 | Maria Skorobogatov als Young Clarice |
| Lamont Arnold als Flower Delivery Man |
| John Hall als State Trooper (uncredited) |
 | Ted Monte als FBI Agent (uncredited) |
 | George A. Romero als FBI Agent in Memphis (uncredited) |
 | John W. Iwanonkiw als Orderly (uncredited) |
 | Robert W. Castle als Priest on Chilton's Plane (uncredited) |
 | Chris McGinn als Autopsy Victim (uncredited) |
 | Gary Goetzman als Guido Paonessa (uncredited) |
 | George Michael als TV Sportscaster |
| Craig McKay | Editor |
| Kristi Zea | Production Design |
| Jonathan Demme | Director |
| Tak Fujimoto | Director of Photography |
| Karen O'Hara | Set Decoration |
| Ted Tally | Screenplay |
| Tim Galvin | Art Direction |
| Colleen Atwood | Costume Design |
| Thomas Harris | Novel |
| Howard Feuer | Casting |
| Edward Saxon | Producer |
| Kenneth Utt | Producer |
| Ronald M. Bozman | Producer |
| Grace Blake | Associate Producer |
| Gary Goetzman | Executive Producer |
| Howard Shore | Original Music Composer |
| John Robotham | Stunt Coordinator |
| Sharon Boyle | Music Supervisor |
| Russell Engels | Gaffer |
| Suzana Peric | Music Editor |
| Ken Regan | Still Photographer |
| Tom Fleischman | Sound Re-Recording Mixer |
| Chris Newman | Production Sound Mixer |
| Kathleen Gerlach | Assistant Costume Designer |
| James Deeth | Thanks |
| Todd Kleitsch | Makeup Effects |
| Walter Robles | Stunts |
| George P. Wilbur | Stunts |
| Allen Weisinger | Makeup Artist |
| Ronald M. Bozman | Assistant Director |
| Dwight Benjamin-Creel | Special Effects |
| Michael Cassidy | Stunts |
| Alan D'Angerio | Hair Designer |
| Marshall Persinger | Post Production Supervisor |
| Denny Caira | Transportation Coordinator |
| Hartsell Taylor | Costume Supervisor |
| John Leonidas | Transportation Captain |
| Michael F. Burke | Electrician |
| Ken Connors | Best Boy Electric |
| Bruce MacCallum | First Assistant Camera |
| S. Bruce Wineinger | Construction Coordinator |
| Brian Hartman | Location Scout |
| Tony C. Jannelli | Camera Operator |
| Mark Streapy | Aerial Camera |
| Francine Byrne | Art Department Coordinator |
| Larry McConkey | Steadicam Operator |
| Gary Kosko | Assistant Art Director |
| Chris Call | Painter |
| C.A. Kelly | Standby Painter |
| Richard Aversa | Grip |
| Ed Lohrer III | Set Dressing Artist |
| Richard Fishwick | Craft Service |
| Kenneth Utt | Unit Production Manager |
| Homer Denison | Orchestrator |
| Ann Miller | Property Master |
| John Fundus | Sound Recordist |
| Matthew Myers | Production Intern |
| Dennis Radesky | Transportation Co-Captain |
| Colleen Sharp | First Assistant Editor |
| Eileen Garrigan | Scenic Artist |
| Larry Jackson | Executive In Charge Of Production |
| Robert F. Warren | Dolby Consultant |
| Judy Arthur | Unit Publicist |
| Dennis Maitland II | Boom Operator |
| Neri Kyle Tannenbaum | Location Manager |
| Catherine Marie McDonald | Set Production Assistant |
| Brian Johnson | Assistant Sound Editor |
| Trish Breganti | Post Production Assistant |
| Skip Lievsay | Sound Designer |
| David Orr | Color Timer |
| Billy Miller | Key Grip |
| Marissa Littlefield | Dialogue Editor |
| Deborah Wallach | ADR Editor |
| Jeffrey Stern | Dialogue Editor |
| Gail Showalter | ADR Editor |
| Fred Rosenberg | Dialogue Editor |
| Philip Stockton | Dialogue Editor |
| Carl Fullerton | Makeup Effects Designer |
| Neal Martz | Makeup Effects Designer |
| Kenneth Turek | Set Dresser |
| Ray Mendez | Animal Wrangler |
| Benjamin Wilson | Wardrobe Assistant |
| Kalina Ivanov | Storyboard Artist |
| Brian S. Osmond | Camera Trainee |
| Mark Burchard | Wardrobe Supervisor |
| Frederika Gray | Key Scenic Artist |
| Dana Sano | Music Coordinator |
| Kyle McCarthy | Second Assistant Director |
| Missy Cohen | Apprentice Sound Editor |
| John Donohue | Dolly Grip |
| Mary A. Kelly | Continuity |
| Lisa Bradley | Assistant Production Coordinator |
| Gina Maria Leonetti | Second Second Assistant Director |
| Marko Costanzo | Foley Artist |
| Walt Oggier | Police Consultant |
| Jonathan Sheinberg | Head of Production |
| Natasha Kinne | Playback Singer |
| John Crowder | Location Coordinator |
| Jeffrey T. Barabe | Production Assistant |
| Tom O'Halloran | Second Assistant Camera |
| Lisa Bromwell | Associate Editor |
| Donna M. Belajac | Additional Casting |
| David Boulton | ADR Recordist |
| Steven Visscher | Foley Editor |
| Frank Kern | Foley Editor |
