 | Rosa Salazar als Alita |
 | Christoph Waltz als Dr. Dyson Ido |
 | Jennifer Connelly als Chiren |
 | Mahershala Ali als Vector |
 | Ed Skrein als Zapan |
 | Jackie Earle Haley als Grewishka |
 | Keean Johnson als Hugo |
 | Lana Condor als Koyomi |
 | Jorge Lendeborg Jr. als Tanji |
 | Eiza González als Nyssiana |
 | Jeff Fahey als McTeague |
 | Idara Victor als Nurse Gerhad |
 | Rick Yune als Master Clive Lee |
 | Derek Mears als Romo |
 | Leonard Wu als Kinuba |
 | Racer Rodriguez als Claymore |
 | Marko Zaror als Ajakutty |
 | Hugo Perez als Jacked Cyborg |
 | Casper Van Dien als Amok |
 | Billy Blair als Zapan's Cronie #1 |
 | Jamie Landau als Zapan's Cronie #2 |
 | Dimitrius Pulido als Cyborg Jacking Victim |
 | Patrick Gathron als Antioch |
 | Elle LaMont als Screwhead |
 | Alex Livinalli als Blue Wingman |
 | Neal Kodinsky als Red Wingman |
| Anthony Bandmann als Mace |
 | Alan Trong als Kumaza |
 | Sam Medina als Stinger |
| Tod Junker als Exploder |
| John Wirt als Cyborg Factory Worker |
 | Darcel Danielle als Young Factory Worker |
| Emma Lindsey als Ido's Daughter |
 | Garrett Warren als Barkeep |
 | Tony LaThanh als Hunter Warrior #1 |
 | Jorge A. Jimenez als Hunter Warrior #2 |
 | Vincent Fuentes als Ed |
 | Ibrahima Thiam als Guitarist |
| Paul de Sousa als Heckler |
 | Gregg Berger als Deckman |
 | David Sobolov als Centurion (voice) |
| Jeff Bottoms als Motorball Announcer (voice) |
 | Michelle Rodriguez als Gelda (uncredited) |
 | Jai Courtney als Jashugan (uncredited) |
 | Edward Norton als Nova (uncredited) |
| Robert Rodriguez | Director |
| Robert Rodriguez | Producer |
| Stephen E. Rivkin | Editor |
| David Valdes | Executive Producer |
| Mary Vernieu | Casting |
| James Cameron | Screenplay |
| James Cameron | Producer |
| Bill Pope | Director of Photography |
| Jon Landau | Producer |
| Daniel Bernhardt | Stunts |
| William Ladd Skinner | Art Direction |
| William Ladd Skinner | Set Designer |
| Catherine Harper | Foley Artist |
| Laeta Kalogridis | Screenplay |
| Susan McNamara | Production Manager |
| Steve Joyner | Production Design |
| Nina Proctor | Costume Design |
| Leslie McDonald | Art Direction |
| Dave Jordan | Music Supervisor |
| David Betancourt | ADR Mixer |
| Tom Holkenborg | Original Music Composer |
| David Bach | ADR Supervisor |
| Don Charles McGovern | Stunts |
| Paula Fairfield | Sound Designer |
| Lauren Mary Kim | Stunts |
| Kathy Kiatta | Truck Costumer |
| Brian Lyster | ADR Recordist |
| Dianne Chadwick | Graphic Designer |
| Justin Yates | Assistant Editor |
| Garrett Warren | Stunt Coordinator |
| Jessie Graff | Stunts |
| Sean P. Egan | Propmaker |
| Ethan Andrus | Sound Mixer |
| Ashlyn Angel | Costume Supervisor |
| Robert D. Cabana | Special Effects |
| Alicia Vela-Bailey | Stunt Double |
| Bob Trevino | Special Effects Supervisor |
| Nick Roberts | ADR Mixer |
| Brian Adler | Visual Effects |
| Andy Nelson | Sound Re-Recording Mixer |
| Craig Henighan | Supervising Sound Editor |
| A. Todd Holland | Art Direction |
| Sean Maxwell | Camera Operator |
| Richard E. Hollander | Visual Effects Supervisor |
| Keil Oakley Zepernick | Stunts |
| Nyima Johnston | Key Set Costumer |
| Jeff B. Adams Jr. | Art Direction |
| Walter Schneider | Set Designer |
| Robert J. Carlyle | Construction Coordinator |
| Katherine Rose | Foley Artist |
| Caylah Eddleblute | Production Design |
| Mike McCutchen | Art Department Coordinator |
| Ken Gaston-Kilgore | Leadman |
| Brad Engleking | Sound Re-Recording Mixer |
| Clark Crawford | Sound Designer |
| Angelo Palazzo | Sound Designer |
| Tim Rakoczy | Supervising Sound Editor |
| Rico Torres | Still Photographer |
| P.K. Munson | Camera Operator |
| Monika Petrillo | Script Supervisor |
| Eric Saindon | Visual Effects Supervisor |
| Shari Ratliff | Set Designer |
| Joe Letteri | Visual Effects Supervisor |
| John 'Fest' Sandau | Gaffer |
| Tom Macdonald | Costumer |
| Mark G. Soper | Visual Effects Producer |
| Jenny Lin | Makeup Department Head |
| Ian Silverstein | Editor |
| Ellen Lampl | Graphic Designer |
| Mark Goellnicht | Steadicam Operator |
| Michelle Wade Byrd | Casting |
| Charles Yusko | Hair Department Head |
| Cynthia Streit | Production Coordinator |
| Jacqueline Fernandez | Makeup Artist |
| Michael Miller | ADR Mixer |
| Skip Kimball | Digital Intermediate Colorist |
| Desirae Wallace | Other |
| Stephen J. Pavelski | Other |
| Logan Cooper | Location Manager |
| Kara Sutherlin | Makeup Artist |
| Lavonna Cupid | Casting Associate |
| Shamim Seifzadeh | Set Designer |
| James Clyne | Conceptual Design |
| Kevin McGill | Camera Operator |
| Riva Cahn Thompson | Casting |
| Riva Cahn Thompson | Casting Associate |
| Hershel Cohen | Digital Intermediate Producer |
| Zach Humphreys | Electrician |
| Yukito Kishiro | Graphic Novel |
| Brian Barela | Set Costumer |
| Brian Bettwy | Assistant Director |
| Brian Bettwy | First Assistant Director |
| Keely Carter | Other |
| Mark Goerner | Conceptual Design |
| Aaron Robert Hall | Set Dressing Artist |
| Dan Leyendecker | Art Department Assistant |
| Megan Montemayor | Set Designer |
| Learda Shkurti | Other |
| Gary Stel | Set Decoration Buyer |
| David Tye | Sculptor |
| Josh Tywater | Set Decoration Buyer |
| Josh Tywater | Other |
| Chris Yoo | Set Designer |
| Feng Zhu | Conceptual Design |
| Travis Guidry | Set Production Assistant |
| Jesse La Flair | Stunts |
| Bret Howe | Casting Associate |
| Kay Colvin | Other |
| Emma Watts | Executive In Charge Of Production |
| Tom Sturgis | Boom Operator |
| John Alcera | Electrician |
| Jay Mahavier | First Assistant Editor |
| Max Juren | Set Dresser |
| Darrin Mann | Foley Mixer |
| Trygge Toven | Music Coordinator |
| Sebastian Trujillo | Lead Animator |
| Raul Mello | Rigging Gaffer |
| Bryon Caldwell | Senior Animator |
| Emile Ghorayeb | Animation Supervisor |
| Shannon Murphy | Music Coordinator |
| Doug Mountain | Sound Editor |
| Vincent Caudeville | Senior Animator |
| Hannah Goldblatt | Key Costumer |
| Sean Thompson | Costume Coordinator |
| Robyn Greer | Electrician |
| William Penson | Electrician |
| Nick Scimeca | Electrician |
| Celina Ferencz | Costumer |
| Todd Smiley | Best Boy Electric |
| Camilo Duarte Franco | Senior Animator |
| Edwina Ting | Senior Animator |
| Hannah Handshy | Additional Hairstylist |
| Nathan Haugaard | Camera Operator |
| Matt McLaughlin | Camera Operator |
| Tyson Smith | Camera Operator |
| David G. Wilson | Camera Operator |
| Eric Pickett | Electrician |
| Ashley Riggs | Electrician |
| Michael Gillespie | Key Grip |
| Jason McKnight | Key Grip |
| Richard Justin Roberts | Lighting Technician |
| Stacey Rice | Casting Associate |
| Iris S Moy Bautista | Extras Casting |
| Niamh Fleming | Extras Casting |
| Kristi Kyle | Extras Casting |
| Ashley Harkrider | Extras Casting Assistant |
| Sweta Vakani | Ager/Dyer |
| Aneesah Woolfolk | Costumer |
| Tessa Paaymans | Costumer |
| Stephanie A. Steel | Key Costumer |
| Tashi Trieu | Digital Intermediate Editor |
| Ludovic Chailloleau | Animation Supervisor |
| Anneka Fris | Lead Animator |
| Francesco Canonico | Senior Animator |
| Benjamin Cheong | Senior Animator |
| David Rimer | Second Assistant Director |
| Joe Howes | Visual Effects |
| Jason Astley | VFX Artist |
| Alexander T.H. Browne | VFX Artist |
| Christian J Smith | Visual Effects |
