 | Jerry Seinfeld als Barry B. Benson (voice) |
 | Renée Zellweger als Vanessa Bloome (voice) |
 | Matthew Broderick als Adam Flayman (voice) |
 | Patrick Warburton als Ken (voice) |
 | John Goodman als Layton T. Montgomery (voice) |
 | Chris Rock als Mooseblood (voice) |
 | Kathy Bates als Janet Benson (voice) |
 | Barry Levinson als Martin Benson (voice) |
 | Larry King als Bee Larry King (voice) |
 | Ray Liotta als Ray Liotta (voice) |
 | Sting als Sting (voice) |
 | Oprah Winfrey als Judge Bumbleton (voice) |
 | Larry Miller als Buzzwell (voice) |
 | Megan Mullally als Trudy (voice) |
 | Rip Torn als Lou Lo Duca (voice) |
 | Michael Richards als Bud Ditchwater (voice) |
 | Mario Joyner als Jackson (voice) |
 | Jim Cummings als Narrator / Graduation Announcer (voice) |
 | Tom Papa als Splitz / Klauss Vanderhayden (voice) |
 | Andy Robin als Jock #2 (voice) |
| David Moses Pimentel als Hector (voice) |
| Chuck Martin als Andy (voice) |
 | Conrad Vernon als Freddy (voice) |
 | David Herman als Buzz / Bob Bumble / Pilot (voice) |
 | Carol Leifer als Press Person #1 (voice) |
 | Jeff Altman als Uncle Carl (voice) |
| Brian Hopkins als Sandy Shrimpkin / TSA Agent (voice) |
 | Tress MacNeille als Jeanette Chung / Mother / Cow (voice) |
| Nathan D. Morrissey als Boy Crying / Timmy (voice) |
| Olivia Mattingly als Little Girl (voice) |
 | Simon J. Smith als Truck Driver / Chet (voice) |
| Geoff Witcher als Press Person #2 / Jock #1 (voice) |
 | John DiMaggio als Janitor / Bailiff (voice) |
| Barry Marder als Waterbug (voice) |
| Sean Bishop als Ladybug (voice) |
| Christophe Lautrette | Art Direction |
| Chris Bancroft | Animation |
| Steve Hickner | Director |
| Rupert Gregson-Williams | Music |
| Jerry Seinfeld | Screenplay |
| Spike Feresten | Screenplay |
| Christina Steinberg | Producer |
| Jane Poole | Costume Design |
| Kevin Andrus | Animation |
| Jerry Seinfeld | Producer |
| David C. Lawson | Director of Photography |
| Barry Marder | Screenplay |
| Andy Robin | Screenplay |
| Simon J. Smith | Director |
| Nick Fletcher | Editor |
| Pat Sito | Art Department Manager |
| Steve Cunningham | Animation |
| Simon Otto | Animation |
| Seth Engstrom | Conceptual Design |
| Alex McDowell | Production Design |
| Jennifer Kluska | Storyboard Artist |
| Gabe Hordos | Art Department Coordinator |
| Hans Zimmer | Executive Music Producer |
| Doug Cooper | Visual Effects Supervisor |
| Cameron Stevning | Associate Producer |
| Tony Cosanella | Production Manager |
| Deven LeTendre | Production Manager |
| Will Files | Supervising Sound Editor |
| Michael Silvers | Supervising Sound Editor |
| Andy Nelson | Sound Mixer |
| Anna Behlmer | Sound Mixer |
| Leslee Feldman | Casting |
| Mark Swift | Co-Producer |
| Joseph R. Thygesen | Additional Editing |
| Christi Soper Hilt | Casting Associate |
| David Yanover | Post Production Supervisor |
| Wayne Hellinger | Post Production Coordinator |
| Mark Schoellkopf | Post Production Coordinator |
| Gene Goins | Projection |
| Randy Thom | Sound Designer |
| Will Files | Sound Designer |
| Scott Guitteau | Sound Effects Editor |
| Kyrsten Mate | Sound Effects Editor |
| Luke Dunn Gielmuda | Foley Supervisor |
| Jana Vance | Foley Artist |
| Dennie Thorpe | Foley Artist |
| Ellen Heuer | Foley Artist |
| Frank Rinella | Foley Mixer |
| Sean England | Foley Recordist |
| Steve Slanec | ADR Editor |
| Thomas J. O'Connell | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Terry Claborn | Color Timer |
| Mo Henry | Negative Cutter |
| Leigh French | ADR Voice Casting |
| Craig Heath | Sound Recordist |
| Blake R. Cornett | Sound Recordist |
| Matt Patterson | Sound Recordist |
| J.J. George | Music Editor |
| Alan Meyerson | Scoring Mixer |
| David G. Derrick Jr. | Story Artist |
