 | Harrison Ford als Indiana Jones |
 | Phoebe Waller-Bridge als Helena |
 | Mads Mikkelsen als Dr. Voller |
 | Boyd Holbrook als Klaber |
 | Olivier Richters als Hauke |
 | Ethann Isidore als Teddy |
 | Toby Jones als Basil Shaw |
 | Antonio Banderas als Renaldo |
 | Karen Allen als Marion |
 | John Rhys-Davies als Sallah |
 | Shaunette Renée Wilson als Mason |
 | Thomas Kretschmann als Colonel Weber |
 | Martin McDougall als Durkin |
 | Alaa Safi als Rahim |
 | Francis Chapman als Young SS Officer |
 | Alfonso Rosario Mandia als Italian Ticket Seller |
| Chase Brown als Larry - Beat Poet Guy |
 | Nasser Memarzia als Archimedes |
| Amedeo Bianchimano als Milanese Suit Man |
 | Anna Francolini als Mandy |
 | Gabby Wong als Chinese Hat Bidder |
 | Adolfo Margiotta als Hector - Salty Diver |
| Niccolo Cancellieri als Sirene Deck Hand |
| Antonio Iorio als Popeye - Lead Scuba Diver |
 | Manuel Klein als SS Stormtrooper |
| Holly Lawton als Young Helena |
| Guy Paul als Prof. Plimpton |
 | Harriet Slater als Fran |
 | Alton Fitzgerald White als Hotel Porter |
 | Ian Porter als Bob - Bartender |
 | Daniel Anderson als Kommando Commander |
 | Cory Peterson als Gov PR Man |
 | Charles Hagerty als Reporter - St Regis |
| Ali Saleh als Jabari - Sallah's Grandson |
| Amara Khan als Alia - Sallah's Granddaughter |
 | Jill Winternitz als Pan Am Stewardess |
 | Billy Postlethwaite als Prof. Donner |
| Clara Greco als Italian Tour Guide |
 | Joe Gallina als Mounted Cop |
| Nicholas Bendall als Filthy Guitar Guy |
| Thulani Storm als Filthy Guitar Guy |
| Edoardo Strano als Archimedes Servant |
 | Angelo Spagnoletti als Archimedes Servant |
| Hicham Ouaraqa als Moroccan Policeman |
| Adil Louchgui als Moroccan Policeman |
| David Mills als TV Reporter |
 | Rhyanna Alexander-Davis als Hippie Girl |
 | Gary Fannin als Armed Intelligence Officer |
 | Gunnar Cauthery als Pilot - Heinkel 111 |
 | Aron von Andrian als Navigator - Heinkel 111 |
| Nikola Trifunovic als SS Kommando |
 | Henry Garrett als Louis - Drunk Airline Pilot |
 | Elena Saurel als Drunk Airline Stewardess |
| Mike Massa als 1944 Indiana Jones Double |
 | Anthony Ingruber als 1944 Indiana Jones Double / Dutch Prince - Bidder |
| Christian Sacha Mehja-Stokes als Rich Kid |
 | Angus Yellowlees als Hippie Student |
| Matthew Staite als SS Guard/Comms Officer |
 | Corrado Invernizzi als Luigi - Italian Engineer |
| Joerg Stadler als Gestapo Officer |
 | Thorston Manderlay als Staff Car Officer |
 | Basil Eidenbenz als Sentry |
 | Johann Heske als Sentry |
| Joshua Broadstone als Overalls |
 | Bruce Lester-Johnson als Screaming Cabbie |
 | Martin Sherman als Drunk - Appliance Store |
 | Allon Sylvain als L'Atlantique Maître D |
 | William Meredith als Con Ed Van Driver |
| Kate Doherty als Basil's Housekeeper |
 | Duran Fulton Brown als Barricade Cop |
| Eliza Mae Kyffin als Screaming Beauty Queen |
| Mauro Cardinali als Maximus |
 | Mark Killeen als Pontimus |
| Bharat Doshi als Miss Jaffrey |
 | Aïssam Bouali als Henchman |
| Douglas Robson als Gunther |
| Mohammed R. Kamel als Hotel Security |
 | Bryony Miller als Confused Student |
| Tiwa Lade als Bubblegum Student |
| Brodie Husband als Sketching Student |
 | Hannah Onslow als Student |
| Frank Marshall | Producer |
| Kathleen Kennedy | Producer |
| John Williams | Original Music Composer |
| Steven Spielberg | Executive Producer |
| Adam Stockhausen | Production Design |
| James Mangold | Director |
| Phedon Papamichael | Director of Photography |
| Simon Emanuel | Producer |
| Philip Kaufman | Characters |
| George Lucas | Characters |
| George Lucas | Executive Producer |
| Dirk Westervelt | Editor |
| Anna Pinnock | Set Decoration |
| Joanna Johnston | Costume Design |
| Peter Dorme | Art Direction |
| Tim Dutton | Art Direction |
| Martin Foley | Supervising Art Director |
| Oliver Goodier | Art Direction |
| Kate Grimble | Art Direction |
| Charlotte Malynn | Art Direction |
| Isona Rigau | Art Direction |
| Quinn Robinson | Art Direction |
| Kyrsten Mate | Sound Designer |
| Gary Rydstrom | Supervising Sound Editor |
| Donald Sylvester | Supervising Sound Editor |
| Hanin Ouidder | Special Effects Supervisor |
| Nicolas Hernandez | Visual Effects Supervisor |
| Michael McCusker | Editor |
| Andrew Buckland | Editor |
| Matthew Wells | Post Production Supervisor |
| A.R. Björklund | Post Production Coordinator |
| Jez Butterworth | Writer |
| John-Henry Butterworth | Writer |
| David Koepp | Writer |
| James Mangold | Writer |
| A.R. Björklund | ADR & Dubbing |
| Gary Rydstrom | Additional Sound Re-Recording Mixer |
| Reetu Aggarwal | VFX Artist |
| Laurens Ehrmann | Visual Effects Supervisor |
| Nic Cupac | In Memory Of |
| Andrew Whitehurst | Visual Effects Supervisor |
| Kathy Siegel | Visual Effects Producer |
| David Webb | First Assistant Director |
| Nathan Woods | Associate Producer |
| Dan Bradley | Second Unit Director |
| Sheila Waldron | Script Supervisor |
| Robert Weaver | Visual Effects Supervisor |
| Ben Cooke | Stunt Coordinator |
| Alistair Williams | Special Effects Supervisor |
| Charlotte Finlay | Costume Supervisor |
| Karen Cohen | Makeup Supervisor |
| Karen Cohen | Hair Supervisor |
| Kirsty Barham | Production Coordinator |
| Lex Donovan | Location Manager |
| Michael DeBeer | In Memory Of |
| Berj Bannayan | Visual Effects Supervisor |
| Keith Sellers | Visual Effects Supervisor |
| Julien Martins | Visual Effects Supervisor |
| Brian Chumney | Foley Supervisor |
| William Ross | Conductor |
| Dave Brennan | Best Boy Electric |
| Tom O'Sullivan | Rigging Gaffer |
| Fiona Cousins | Special Effects Coordinator |
| Siobhan Walsh | Construction Coordinator |
| Skip Kimball | Colorist |
| Edoardo Martino | Animal Wrangler |
| Fredrik T. Hiebert | Thanks |
| Alex King | Other |
| Nathan Woods | Production Controller |
| John Williams | Orchestrator |
| John Williams | Conductor |
| William Ross | Orchestrator |
| Tom Williams | Other |
| Nina Gold | Casting |
| Anthony Dixon | Co-Producer |
| Candice D. Campos | Co-Producer |
| Zakaria Alaoui | Producer |
| Oli van der Vijver | Art Direction |
| Jake Hall | Art Direction |
| Sam Leake | Art Direction |
| Andrew Palmer | Art Direction |
| Elicia Scales | Art Direction |
| Karen Asano-Myers | Hairstylist |
| Sophie Ashworth | Prosthetic Makeup Artist |
| Bill Corso | Makeup Artist |
| Sally Crouch | Makeup & Hair |
| Frances Hannon | Prosthetic Designer |
| Lorraine Hill | Prosthetics |
| Angie Mudge | Makeup Supervisor |
| Adrian Rigby | Makeup & Hair |
| Charlotte Rogers | Prosthetic Makeup Artist |
| Jo Barrass-Short | Makeup & Hair |
| Debbie Black | Makeup & Hair |
| Jean Carlos de Blas | Makeup & Hair |
| Madeleine Drewell | Makeup & Hair |
| Amy Haida | Makeup & Hair |
| Samuel James | Wigmaker |
| Olivia Jerrard | Makeup & Hair |
| Gabor Kerekes | Makeup & Hair |
| Chris Lyons | Special Effects Makeup Artist |
| Waldo Mason | Prosthetics |
| Sarah Nuth | Prosthetic Makeup Artist |
| Clementine Ollerenshaw | Makeup & Hair |
| Emma Leigh Porter | Hairstylist |
| Lucy Rowley | Makeup & Hair |
| Emma J. Slater | Makeup & Hair |
| Hazel d Smith | Makeup & Hair |
| Mona Turnbull | Makeup & Hair |
| Chiara Ugolini | Makeup & Hair |
| Leanne Alison White | Makeup & Hair |
| Andrew Whiteoak | Makeup & Hair |
| Dan Adams | Stunts |
| Roman Neso Laupmaa | Stunts |
| Joel Adrian | Stunts |
| James Apps | Stunts |
| Miguel Arregui | Stunts |
| Mehrzad Asgi-Kermani | Stunts |
| Luciano Bacheta | Stunts |
| Abdelaaziz Attougui | Stunts |
| Adam Basil | Stunts |
| Matthew Bell | Stunts |
| Lily-May Licorish | Visual Effects Coordinator |
| Stuart Wilson | Production Sound Mixer |
| Paul Massey | Sound Re-Recording Mixer |
| Juan Peralta | Sound Re-Recording Mixer |
| David Giammarco | Sound Re-Recording Mixer |
| Ramiro Belgardt | Music Editor |
| Ted Caplan | Music Editor |
| Blake Simon | Associate Producer |
| Mike Massa | Stunt Coordinator |
| Gabriel Hardman | Storyboard Artist |
| Frances Hannon | Makeup Designer |
| Frances Hannon | Hair Designer |
| Simon Mills | Production Manager |
| Kelly Lee | Production Supervisor |
| David Appleby | Key Grip |
| John Berri | Additional Editor |
| Josh Gold | Sound Designer |
| Warren Hendriks | Sound Designer |
| John Berri | VFX Editor |
| Matt Blouin | VFX Editor |
| Sandra Grubb | First Assistant Editor |
| Daniel M. Nussbaum | First Assistant Editor |
| Christopher Rucinski | Assistant Editor |
| Polly McKinnon | Dialogue Editor |
| Erin Michael Rettig | Sound Engineer |
| George Hart | Sound Engineer |
| Emma Sawyer | Script Coordinator |
| Eric A. Norris | Sound Effects Editor |
| Lee Gilmore | Sound Effects Editor |
| Samson Neslund | Sound Effects Editor |
| David Chrastka | Sound Effects Editor |
| Rich Danhakl | Sound Effects Editor |
| Jana Vance | Foley Artist |
| Ronni Brown | Foley Artist |
| Richard Duarte | Foley Mixer |
| Chris Manning | Foley Editor |
| Greg J. Peterson | Foley Editor |
| David Betancourt | ADR Mixer |
| Dave Tourkow | ADR Engineer |
| Christine Sirois | ADR Recordist |
| Mark Appleby | ADR Mixer |
| Simon Diggins | ADR Mixer |
| Mike Tehrani | ADR Mixer |
| Jonathan Olley | Still Photographer |
| Moira Houlihan | Unit Publicist |
| Paul Biddiss | Military Consultant |
