 | Jeremy Irons als Beverly / Elliot Mantle |
 | Geneviève Bujold als Claire Niveau |
 | Heidi von Palleske als Cary |
 | Barbara Gordon als Danuta |
 | Shirley Douglas als Laura |
 | Stephen Lack als Wolleck / Anders Wolleck |
 | Nick Nichols als Leo |
 | Lynne Cormack als Arlene |
| Damir Andrei als Birchall |
| Miriam Newhouse als Mrs. Bookman |
| David Hughes als Superintendent |
| Richard W. Farrell als Dean of Medicine |
| Warren Davis als Anatomy Class Supervisor |
| Marsha Moreau als Raffaella |
 | Denis Akiyama als Pharmacist |
 | Dee McCafferty als Surgeon |
 | Jane Luk als Lecture-Hall Nurse |
 | Jill Hennessy als Mimsy |
 | David Cronenberg als Obstetrician (uncredited) |
| Bob Bainborough als Mr. Glaser |
| David Cronenberg | Director |
| David Cronenberg | Producer |
| David Cronenberg | Writer |
| Peter Suschitzky | Director of Photography |
| Ronald Sanders | Editor |
| Howard Shore | Original Music Composer |
| James McAteer | Art Direction |
| Deirdre Bowen | Casting |
| Carol Spier | Production Design |
| David Evans | Sound Editor |
| Denise Cronenberg | Costume Design |
| Elinor Rose Galbraith | Set Decoration |
| Sylvio Tabet | Executive Producer |
| Carol Baum | Executive Producer |
| David Giammarco | Sound Editor |
| Bari Wood | Novel |
| Jack Geasland | Novel |
| Norman Snider | Writer |
| Don White | Sound Re-Recording Mixer |
| Richard Cadger | Sound Editor |
| Wayne Griffin | Sound Editor |
| Shonagh Jabour | Makeup Artist |
| Marc Boyman | Producer |
| John Board | Associate Producer |
| Andy Nelson | Sound Re-Recording Mixer |
| Dug Rotstein | Script Supervisor |
| Ivan Lynch | Hair Designer |
| Attila Dory | Still Photographer |
| Bryan Day | Sound Mixer |
| Richard Spiegelman | Transportation Coordinator |
| Eva Coudouloux | Makeup Artist |
